Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures.
Henderson SE, Yu K, Alder KD, Ibe IK, Lee FY, Lindskog DM. Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures. Instructional Course Lectures 2019, 68: 607-612. PMID: 32032089.Peer-Reviewed Original ResearchConceptsPathologic fractureSkeletal metastasesTibial reconstructionCommon reconstructive optionsRisk of complicationsSoft tissue involvementHistory of radiationImproved patient outcomesSubsequent revision proceduresLarge skeletal defectsGoal of reconstructionSystemic therapyGoal of managementPatient outcomesSurgical reconstructionReconstructive optionsRevision proceduresEndoprosthesis implantationIntramedullary nailImplant failureLarge bone defectsMetastasisBone defectsSkeletal defectsFracturesMetastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss.
Ibe IK, Sahlstrom A, White A, Henderson SE, Lee FY. Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss. Instructional Course Lectures 2019, 68: 547-556. PMID: 32032068.Peer-Reviewed Original ResearchConceptsCancer-induced bone lossBone lossBone metastasesMetastatic bone diseaseCancer cellsDegree of osteolysisNormal bone homeostasisBenefit of patientsOsteolytic metastasesSkeletal metastasesPatient functionSurgical stabilizationWorse prognosisLocal bone massBone massMetastatic cancerBone diseaseRadiation therapyTherapeutic modalitiesBone homeostasisImmune systemOverall outcomeMetastasisBone remodelingPatients