2020
Comparative Genomics within and across Bilaterians Illuminates the Evolutionary History of ALK and LTK Proto-Oncogene Origination and Diversification
Dornburg A, Wang Z, Wang J, Mo ES, López-Giráldez F, Townsend JP. Comparative Genomics within and across Bilaterians Illuminates the Evolutionary History of ALK and LTK Proto-Oncogene Origination and Diversification. Genome Biology And Evolution 2020, 13: evaa228. PMID: 33196781, PMCID: PMC7851593, DOI: 10.1093/gbe/evaa228.Peer-Reviewed Original ResearchConceptsLeukocyte tyrosine kinaseEvolutionary historyPhylogenetic analysisProtein-coding genesComparative genomic analysisEarly embryonic expressionMetazoan genomesComparative genomicsPhylogenetic contextModel organismsEmbryonic expressionModel speciesHuman genesKey genesGenomic analysisImportant genesMammal systemsFunctional convergenceTyrosine kinaseMolecular homologyGenesFunctional roleVertebratesMammal modelsHomology
2015
Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol
Del Pino Sans J, Krishnan S, Aggison LK, Adams HL, Shrikant MM, López-Giráldez F, Petersen SL. Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol. Neuroscience 2015, 303: 312-322. PMID: 26166732, DOI: 10.1016/j.neuroscience.2015.07.008.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, NewbornCELF ProteinsEstradiolFemaleGene Expression Regulation, DevelopmentalHypothalamus, AnteriorMaleNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisPregnancyRatsRats, Sprague-DawleyReceptors, GABAReceptors, GlutamateRNA, MessengerSex DifferentiationTranscriptomeConceptsAnteroventral periventricular nucleusE2-treated femalesPolymerase chain reaction studiesHormone release patternsMetabolites of testosteroneMale anteroventral periventricular nucleusFemale anteroventral periventricular nucleusQuantitative polymerase chain reaction studiesE2 effectsDimorphic neural structuresGender-specific functionsPeriventricular nucleusDimorphic nucleusPerinatal testisHigher mRNA levelsMRNA levelsE2Protein 2Neural structuresSex-specific genesTranslation of mRNAsSex differencesCUG triplet repeatMalesMicroarray analysis