2016
The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex
McKenzie J, Lopez-Giraldez F, Delecluse HJ, Walsh A, El-Guindy A. The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex. PLOS Pathogens 2016, 12: e1006008. PMID: 27855219, PMCID: PMC5113994, DOI: 10.1371/journal.ppat.1006008.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternChromatin ImmunoprecipitationEpstein-Barr Virus InfectionsGene Expression Regulation, ViralGene Knockdown TechniquesHEK293 CellsHerpesvirus 4, HumanHigh-Throughput Nucleotide SequencingHumansImmune EvasionReal-Time Polymerase Chain ReactionViral ProteinsViral Regulatory and Accessory ProteinsViral Structural ProteinsConceptsPre-initiation complexViral pre-initiation complexEpstein-Barr virusLate genesViral gene expressionGene regulatorsViral structural proteinsGene expressionStructural proteinsImmunomodulatory proteinsHost immune surveillanceAntiviral immune responseChIP-seq analysisProtein kinase BGLF4Presence of siRNAsEB virusPrimary infectionImmune surveillanceImmune responseAntiviral drugsImmune evasionGene productsViral pathogenesisBCRF1Gamma herpesvirus
2014
Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition.
Bahal R, Quijano E, McNeer NA, Liu Y, Bhunia DC, Lopez-Giraldez F, Fields RJ, Saltzman WM, Ly DH, Glazer PM. Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition. Current Gene Therapy 2014, 14: 331-42. PMID: 25174576, PMCID: PMC4333085, DOI: 10.2174/1566523214666140825154158.Peer-Reviewed Original ResearchConceptsGene editingSite-specific genome editingEfficient intracellular deliverySite-specific formationIntracellular deliveryGamma PNAsGenome editingAltered helical structureGenomic DNANext generationDonor DNAΓPNANovel strategyMouse bone marrow cellsNanoparticlesDNA repairEditingMouse bone marrowHomopurine sitesSequence restrictionDetectable toxicityBone marrow cellsDNAHereinHelical structure