2018
Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture
Cheng FY, Fleming JT, Chiang C. Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture. Developmental Biology 2018, 440: 152-166. PMID: 29792854, PMCID: PMC6014626, DOI: 10.1016/j.ydbio.2018.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell DifferentiationCell DivisionCell ProliferationCells, CulturedCerebellar CortexCerebellar NeoplasmsCerebellumDevelopmental DisabilitiesHedgehog ProteinsMiceNervous System MalformationsNeural Stem CellsNeurogliaNeuronsPurkinje CellsSignal TransductionWnt Signaling PathwayConceptsCerebellar granule neuron precursorsBergmann gliaDay of ablationSevere cerebellar hypoplasiaCentral nervous system architectureCGNP proliferationGranule neuron precursorsRole of ShhBergmann glial fibersNervous system architectureCerebellar hypoplasiaGlial fibersCortical expansionPurkinje cellsNeuron precursorsGlial networkSpecific ablationGliaNeural tissueNeuronal specificationSignificant decreaseCerebellar sizeShh pathwayMutant cerebellumHh pathway
2017
Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex
Ryan KE, Kim PS, Fleming JT, Brignola E, Cheng FY, Litingtung Y, Chiang C. Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex. Developmental Biology 2017, 432: 165-177. PMID: 28974424, PMCID: PMC5694378, DOI: 10.1016/j.ydbio.2017.09.036.Peer-Reviewed Original Research
2012
Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation
Cheng FY, Huang X, Sarangi A, Ketova T, Cooper MK, Litingtung Y, Chiang C. Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation. PLOS ONE 2012, 7: e35541. PMID: 22539980, PMCID: PMC3335071, DOI: 10.1371/journal.pone.0035541.Peer-Reviewed Original ResearchConceptsSonic hedgehog-driven medulloblastomaGlutamatergic granule neuronsBergmann glial cellsCentral nervous systemChoroid plexus epithelial cellsCell typesGenetic fate-mapping studiesGlial cell typesChoroid plexus epitheliumUnipolar brush cellsCerebellar granule neuron precursorsPlexus epithelial cellsGranule neuron precursorsGABAergic interneuronsNeural cell typesGlial cellsPurkinje neuronsNervous systemGranule neuronsRoof plateWhite matterPlexus epitheliumBrush cellsNeuron precursorsSonic hedgehog (Shh) signaling