The use of rhDNAse in severely ill, non-intubated adult asthmatics refractory to bronchodilators: A pilot study
Silverman RA, Foley F, Dalipi R, Kline M, Lesser M. The use of rhDNAse in severely ill, non-intubated adult asthmatics refractory to bronchodilators: A pilot study. Respiratory Medicine 2012, 106: 1096-1102. PMID: 22580235, DOI: 10.1016/j.rmed.2012.04.002.Peer-Reviewed Original ResearchConceptsAcute asthmaSevere acute asthmaSevere asthma episodesUse of rhDNasePrimary study endpointNon-fatal casesPost-randomization time pointsViscoelasticity of sputumBronchodilator therapyIpratropium treatmentPlacebo patientsSymptomatic asthmaticsFatal asthmaAdult asthmaticsClinical improvementMucous pluggingIll adultsStudy endpointStandardized careAsthma episodesEmergency departmentClinical trialsTherapeutic roleMucolytic agentTreatment groups