2022
Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference
Pashankar F, Hanley K, Lockley M, Stoneham S, Nucci MR, Reyes-Múgica M, Elishaev E, Vang R, Veneris J, Rytting H, Olson T, Hazard K, Covens A, Arora R, Billmire D, Al-Ibraheemi A, Ulbright TM, Frazier L, Hirsch MS. Addressing the diagnostic and therapeutic dilemmas of ovarian immature teratoma: Report from a clinicopathologic consensus conference. European Journal Of Cancer 2022, 173: 59-70. PMID: 35863107, DOI: 10.1016/j.ejca.2022.06.006.Peer-Reviewed Original ResearchConceptsOvarian immature teratomaImmature teratomaGerm cell tumor elementsSerum alpha-fetoproteinGerm cell tumorsYolk sac tumorSerum tumor biomarkersForm of sarcomaTherapeutic dilemmaSac tumorRare subtypeSomatic malignancyCell tumorsNeuroectodermal elementsNeuroectodermal componentConsensus conferenceAlpha-fetoproteinTumor elementsManagement dilemmaAdult womenPractice differencesTumor biomarkersTeratomaTumorsClinicopathologic conference
2019
GCT-40 Alpha-fetoprotein (AFP) as a predictor of outcome for children with germ cell tumours: A report from the Malignant Germ Cell International Consortium (MaGIC)
O’Neill A, Xia C, Krailo M, Shaikh F, Pashankar F, Billmire D, Olson T, Amatruda J, Villaluna D, Huang L, Malogolowkin M, Rodriguez-Galindo C, Frazier A. GCT-40 Alpha-fetoprotein (AFP) as a predictor of outcome for children with germ cell tumours: A report from the Malignant Germ Cell International Consortium (MaGIC). European Urology Open Science 2019, 18: 19. DOI: 10.1016/s1569-9056(19)32507-2.Peer-Reviewed Original ResearchGCT-10 Outcomes of adolescent males with extracranial metastatic germ cell tumours compared with children and young adults: A report from the Malignant Germ Cell Tumour International Consortium (MaGIC) group
Shaikh F, Stark D, Dang H, Xia C, Krailo M, Stenning S, Pashankar F, Rodriguez-Galindo C, Olson T, Depani S, Stoneham S, Nicholson J, Murray M, Amatruda J, Billmire D, Fonseca A, Frazier A. GCT-10 Outcomes of adolescent males with extracranial metastatic germ cell tumours compared with children and young adults: A report from the Malignant Germ Cell Tumour International Consortium (MaGIC) group. European Urology Open Science 2019, 18: 9. DOI: 10.1016/s1569-9056(19)32477-7.Peer-Reviewed Original ResearchAlfa-feto protein (AFP) as a predictor of outcome for children with germ cell tumors: A report from the malignant germ cell international consortium.
O'Neill A, Xia C, Krailo M, Shaikh F, Pashankar F, Billmire D, Olson T, Amatruda J, Villaluna D, Malogolowkin M, Rodriguez-Galindo C, Frazier A. Alfa-feto protein (AFP) as a predictor of outcome for children with germ cell tumors: A report from the malignant germ cell international consortium. Journal Of Clinical Oncology 2019, 37: 10036-10036. DOI: 10.1200/jco.2019.37.15_suppl.10036.Peer-Reviewed Original ResearchEvent-free survivalGerm cell tumorsAFP declinePediatric patientsCell tumorsTumor marker declineStart of chemotherapyDays of chemotherapyStandard-risk diseaseYears of ageAdult patientsRisk diseasePoor prognosisSerum AFPMarker declineStratified analysisPatientsChemotherapyTumorsInitial daysDaysDeclinePrognosisDisease
2018
P3BEP (ANZUP 1302): An international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours (GCTs).
Grimison P, Lawrence N, Stockler M, Martin A, Yip S, Wong N, Yeung A, Friedlander M, Mazhar D, Pashankar F, Quinn D, McDermott R, Walker R, Winstanley M, Hanning F, Weickhardt A, Stevanovic A, Davis I, Toner G. P3BEP (ANZUP 1302): An international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours (GCTs). Journal Of Clinical Oncology 2018, 36: tps4596-tps4596. DOI: 10.1200/jco.2018.36.15_suppl.tps4596.Peer-Reviewed Original Research
2017
Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study
Dicken BJ, Billmire DF, Krailo M, Xia C, Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Rescorla FJ, Egler RA, Ross JH, Rodriguez‐Galindo C, Frazier AL. Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study. Pediatric Blood & Cancer 2017, 65 PMID: 29286555, PMCID: PMC6219870, DOI: 10.1002/pbc.26913.Peer-Reviewed Original ResearchConceptsOvarian germ cell tumorsMalignant ovarian germ cell tumorsGerm cell tumorsEvent-free survivalNon-GD patientsOverall survivalGonadal dysgenesisMalignant germ cell tumorsAggressive chemotherapy regimenHigh-risk groupNondysgerminomatous tumorsChemotherapy regimenPure dysgerminomaPediatric patientsSac tumorBilateral gonadectomyCell tumorsWorse outcomesEmbryonal carcinomaPatientsStreak ovariesDysgenetic gonadsTumorsY chromosome materialGonadoblastomaImmature Ovarian Teratoma
Faure-Conter C, Pashankar F. Immature Ovarian Teratoma. Journal Of Pediatric Hematology/Oncology 2017, 39: 487-489. PMID: 28859031, DOI: 10.1097/mph.0000000000000950.Peer-Reviewed Original ResearchConceptsOvarian immature teratomaImmature teratomaPure ovarian immature teratomaFIGO stage IARole of chemotherapyImmature ovarian teratomaGrade 1 tumorsStandard of careAdjuvant chemotherapyAdult oncologistsMalignant relapseStage IAPediatric seriesOvarian teratomaPediatric teamAdult womenChemotherapyTumorsTeratomaUrgent needRelapsePatientsSurgeryOncologistsPediatricsGerm Cell Tumors of the Ovary
Matei D, Frazier A, Hurteau J, Pashankar F. Germ Cell Tumors of the Ovary. 2017, 518-532. DOI: 10.1002/9781119196235.ch35.Peer-Reviewed Original ResearchGerm cell tumorsOvarian germ cell tumorsCell tumorsNondysgerminomatous germ cell tumorsPrimitive germ cell tumorsMixed germ cell tumorCornerstone of treatmentYolk sac tumorPrinciples of diagnosisLong-term toxicityQuality of lifeCurrent multidisciplinary approachLonger life expectancyNongestational choriocarcinomaHistological typeSac tumorRare tumorEmbryonal carcinomaMost womenTumorsYoung womenLife expectancyMultidisciplinary approachWomenTreatmentReduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group
Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Villaluna D, Krailo M, Billmire DF, Rescorla FJ, Egler RA, Dicken BJ, Ross JH, Schlatter M, Rodriguez-Galindo C, Frazier AL. Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group. Journal Of Clinical Oncology 2017, 35: jco.2016.67.654. PMID: 28240974, PMCID: PMC5455599, DOI: 10.1200/jco.2016.67.6544.Peer-Reviewed Original ResearchConceptsMalignant germ cell tumorsEvent-free survivalCycles of PEBEFS ratesGerm cell tumorsOncology GroupCell tumorsExtracranial malignant germ cell tumorsReduction of therapyChildren's Oncology GroupSingle-arm trialLow-stage tumorsHigh-stage tumorsAdministration of cisplatinEligible patientsComparable patientsHistorical cohortPatientsTumorsStatistical significanceComparable childrenPhase 3ChildrenP-valueOne-sided p-value
2016
Reduced and compressed cisplatin-based chemotherapy in children and adolescents with intermediate-risk extracranial malignant germ cell tumors: A report from the Children’s Oncology Group.
Shaikh F, Cullen J, Olson T, Pashankar F, Malogolowkin M, Amatruda J, Villaluna D, Krailo M, Billmire D, Rescorla F, Egler R, Dicken B, Ross J, Schlatter M, Rodriguez-Galindo C, Frazier A. Reduced and compressed cisplatin-based chemotherapy in children and adolescents with intermediate-risk extracranial malignant germ cell tumors: A report from the Children’s Oncology Group. Journal Of Clinical Oncology 2016, 34: 10512-10512. DOI: 10.1200/jco.2016.34.15_suppl.10512.Peer-Reviewed Original Research
2015
The Role of Registries and Tumor Banking in Rare Pediatric Tumors
Pashankar F, Bisogno G, Ribeiro R, Messinger Y, Schultz K, Rodriguez-Galindo C. The Role of Registries and Tumor Banking in Rare Pediatric Tumors. Current Pediatrics Reports 2015, 3: 128-136. DOI: 10.1007/s40124-015-0077-9.Peer-Reviewed Original ResearchRare pediatric tumorTumor RegistryRare tumorPediatric tumorsDevelopment of registriesRole of registriesTypes of registriesTherapeutic guidelinesPediatric malignanciesCo-operative groupsSingle tumorMolecular pathogenesisRegistryHeterogenous groupTumorsOrphan diseaseTissue repositoryUnderstanding carcinogenesisTumor bankingGroupMalignancyPathogenesisDisease
2012
Children's Oncology Group's 2013 blueprint for research: Rare tumors
Rodriguez‐Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G, Committee O. Children's Oncology Group's 2013 blueprint for research: Rare tumors. Pediatric Blood & Cancer 2012, 60: 1016-1021. PMID: 23255219, PMCID: PMC4304764, DOI: 10.1002/pbc.24428.Peer-Reviewed Original ResearchConceptsGerm cell tumorsCell tumorsRare cancersChildren's Oncology Group's 2013 blueprintInternational phase 3 clinical trialsPhase 3 clinical trialsEvidence-based definitionIntraocular retinoblastomaAdvanced carcinomaRisk stratificationInfrequent malignancyRare tumorClinical trialsClinical studiesLiver tumorsTumorsBiologic studiesChildrenCancerRetinoblastomaCarcinomaMalignancyHepatoblastomaYearsTrialsDevelopment of a Therapeutic Approach to Rare Cancers in Children
Pashankar FD, Rodriguez-Galindo C, Pappo A. Development of a Therapeutic Approach to Rare Cancers in Children. Journal Of Pediatric Hematology/Oncology 2012, 34: s37-s38. PMID: 22525404, DOI: 10.1097/mph.0b013e31824e378e.Peer-Reviewed Original ResearchManagement of Ovarian and Testicular Sex Cord-stromal Tumors in Children and Adolescents
Schultz KA, Schneider DT, Pashankar F, Ross J, Frazier L. Management of Ovarian and Testicular Sex Cord-stromal Tumors in Children and Adolescents. Journal Of Pediatric Hematology/Oncology 2012, 34: s55-s63. PMID: 22525408, DOI: 10.1097/mph.0b013e31824e3867.Peer-Reviewed Original ResearchConceptsSex cord-stromal tumorsTesticular sex cord-stromal tumorsOvarian sex cord-stromal tumorsManagement of ovarianTesticular stromal tumorsHigh-risk diseaseGerm cell neoplasmsOptimal treatment strategyMultiagent chemotherapyObstetrics classificationPalpable massBenign courseRisk diseaseStromal tumorsRare tumorSpecific genetic syndromesOvarian carcinomaCell neoplasmsTreatment strategiesHormone productionTumorsGenetic syndromesInternational FederationAdditional researchChildrenManagement of Pancreatoblastoma in Children and Young Adults
Glick RD, Pashankar FD, Pappo A, LaQuaglia MP. Management of Pancreatoblastoma in Children and Young Adults. Journal Of Pediatric Hematology/Oncology 2012, 34: s47-s50. PMID: 22525406, DOI: 10.1097/mph.0b013e31824e3839.Peer-Reviewed Original ResearchConceptsAppropriate cross-sectional imagingComplete surgical resectionLarge retroperitoneal massMalignant pancreatic tumorsGoal of therapyHigh recurrence rateRare childhood tumorCross-sectional imagingYoung childrenAdjuvant chemotherapyCurative resectionNeoadjuvant chemotherapyMetastatic diseaseSurgical resectionInitial diagnosisRetroperitoneal massChemotherapeutic regimensRecurrence rateMean ageRare tumorPancreatic tumorsTissue diagnosisChildhood tumorsSectional imagingTumors
2005
MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use.
Pashankar FD, O'Dorisio MS, Menda Y. MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use. Journal Of Nuclear Medicine 2005, 46 Suppl 1: 55s-61s. PMID: 15653652.Peer-Reviewed Original ResearchMeSH Keywords3-IodobenzylguanidineAnimalsChildChild, PreschoolClinical Trials as TopicHumansInfantInfant, NewbornNeuroblastomaOctreotidePatient SelectionPentetic AcidPractice Guidelines as TopicPractice Patterns, Physicians'Radiation InjuriesRadionuclide ImagingRadiopharmaceuticalsSomatostatinTreatment OutcomeConceptsSolid tumorsCertain pediatric tumorsSomatostatin receptor analoguesPediatric solid tumorsMetaiodobenzylguanidine scanNuclear imaging techniquesBone scanPediatric tumorsFalse transmitterTherapeutic useCell membrane receptorsReceptor analoguesYoung adultsTumorsMolecular targetsCurrent conceptsMIBGScansMembrane receptorsSpecific ligandsImaging techniquesChildrenSubcellular organellesCellular proteinsDiagnosis