Farren Isaacs, PhD
Professor of Molecular, Cellular and Developmental BiologyDownloadHi-Res Photo
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Professor of Molecular, Cellular and Developmental Biology
Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Center for RNA Science and Medicine
- Genomics, Genetics, and Epigenetics
- Microbiology
- Molecular Cell Biology, Genetics and Development
- Plant Molecular Biology
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
Education & Training
- PhD
- Boston University, Bioinformatics (2003)
Research
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Overview
Medical Research Interests
Bioengineering; Gene Editing; Gene Regulatory Networks; Genetic Variation; Genetics; Genomics; Glioblastoma; Synthetic Biology; Systems Biology
ORCID
0000-0001-8615-8236- View Lab Website
Isaacs Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Farren Isaacs's published research.
Publications Timeline
A big-picture view of Farren Isaacs's research output by year.
Research Interests
Research topics Farren Isaacs is interested in exploring.
Jason Crawford, PhD
Jesse Rinehart, PhD
Monkol Lek, PhD
Ruslan Medzhitov, PhD
Stephen Dellaporta, PhD
Svetlana Rogulina
16Publications
3,516Citations
Gene Editing
Genetic Variation
Publications
2026
Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning
Wang S, Wu X, Moreno M, Oh J, Dellaporta S, Crawford J, Isaacs F. Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning. The Plant Genome 2026, 19: e70284. PMID: 42557532, PMCID: PMC13459069, DOI: 10.1002/tpg2.70284.Peer-Reviewed Original ResearchCas3-mediated genome reduction: demonstration in Cupriavidus necator H16 improves growth on heterotrophic and autotrophic carbon sources
Fulk E, Swart R, Nakamura A, Quinto L, Nogué V, Calvey C, Tharun I, Isaacs F, Johnson C. Cas3-mediated genome reduction: demonstration in Cupriavidus necator H16 improves growth on heterotrophic and autotrophic carbon sources. Nucleic Acids Research 2026, 54: gkag753. PMID: 42549571, PMCID: PMC13434340, DOI: 10.1093/nar/gkag753.Peer-Reviewed Original ResearchAltmetricIntegrase-On-Demand: bioprospecting integrases for targeted genomic insertion of genetic cargo
McClain H, Lowrey L, Quinto L, Torrance E, Gagliano T, Isaacs F, Schoeniger J, Williams K, Mageeney C. Integrase-On-Demand: bioprospecting integrases for targeted genomic insertion of genetic cargo. Nucleic Acids Research 2026, 54: gkag106. PMID: 41657243, PMCID: PMC12884075, DOI: 10.1093/nar/gkag106.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Building Decision Points Into Research’s Slipperiest Slopes
Evans J, Callender C, Devaraj N, Isaacs F, Kaebnick G. Building Decision Points Into Research’s Slipperiest Slopes. Issues In Science And Technology 2025, 41: 78-82. DOI: 10.58875/nlse3159.Peer-Reviewed Original ResearchCitationsPrecision multiplexed base editing in human cells using Cas12a-derived base editors
Schweitzer A, Adams E, Nguyen M, Lek M, Isaacs F. Precision multiplexed base editing in human cells using Cas12a-derived base editors. Nature Communications 2025, 16: 5061. PMID: 40449999, PMCID: PMC12126522, DOI: 10.1038/s41467-025-59653-x.Peer-Reviewed Original ResearchCitationsAltmetricSynthetic Genetic Elements Enable Rapid Characterization of Inorganic Carbon Uptake Systems in Cupriavidus necator H16
Nakamura A, Fulk E, Johnson C, Isaacs F. Synthetic Genetic Elements Enable Rapid Characterization of Inorganic Carbon Uptake Systems in Cupriavidus necator H16. ACS Synthetic Biology 2025, 14: 943-953. PMID: 40048245, PMCID: PMC11934965, DOI: 10.1021/acssynbio.4c00869.Peer-Reviewed Original ResearchCitationsEngineering a genomically recoded organism with one stop codon
Grome M, Nguyen M, Moonan D, Gurara K, Wang S, Hemez C, Stenton B, Cao Y, Radford F, Kornaj M, Patel J, Prome M, Rogulina S, Sozanski D, Tordoff J, Rinehart J, Isaacs F. Engineering a genomically recoded organism with one stop codon. Nature 2025, 639: 512-521. PMID: 39910296, PMCID: PMC11903333, DOI: 10.1038/s41586-024-08501-x.Peer-Reviewed Original ResearchThis study investigates the engineering of a genomically recoded organism, demonstrating the reassignment of stop codons to enable precise incorporation of synthetic amino acids into proteins for biotechnological applications.
2024
Confronting risks of mirror life
Adamala K, Agashe D, Belkaid Y, Bittencourt D, Cai Y, Chang M, Chen I, Church G, Cooper V, Davis M, Devaraj N, Endy D, Esvelt K, Glass J, Hand T, Inglesby T, Isaacs F, James W, Jones J, Kay M, Lenski R, Liu C, Medzhitov R, Nicotra M, Oehm S, Pannu J, Relman D, Schwille P, Smith J, Suga H, Szostak J, Talbot N, Tiedje J, Venter J, Winter G, Zhang W, Zhu X, Zuber M. Confronting risks of mirror life. Science 2024, 386: 1351-1353. PMID: 39666824, DOI: 10.1126/science.ads9158.Peer-Reviewed Original ResearchCitationsAltmetricEnabling equitable and affordable access to novel therapeutics for pandemic preparedness and response via creative intellectual property agreements
Griffen E, Boulet P, Albrecht R, Akbar A, Amick I, Aschenbrenner J, Balcomb B, Barr H, Battu H, Benjamin J, Bloom J, Boby M, Bogyo M, Bolon D, Boulet P, Clerkin A, Cadagan R, Capkin E, Castellanos M, Chandran A, Chen S, Chodera J, Cole D, Cousins D, Cuadrado S, de Godoy A, Dhalech A, Diaz R, DiPoto M, Doherty J, Dotson D, Duggan S, Evans M, Fairhead M, Fate G, Fearon D, Federov O, Ferla M, Ferreira L, Fieseler K, Filep M, Flores D, Flynn J, Fraisse L, Ronen G, Gad B, Garcia-Sastre A, Gathecha C, Gayvert J, Giroud C, Parejo C, Goldberger E, Golding M, Gordon M, Griffen E, Hannon W, Hassan H, Henry M, Hertzman R, Horton J, Huang F, Huang Q, Iacovella C, Isaacs F, James D, Jameson M, Kaminow B, Kenney I, Kenton N, Kirkegaard K, Koekemoer L, Kurtyilmaz N, La V, Lahav N, Lambert M, Lavie M, Lee A, Lefker B, Lemons K, Lindenbach B, Lithgo R, Livnah E, London N, Lynch N, MacDermott H, MacLean E, Marples P, Marsden B, McGovern B, Minh D, Mugeni M, Nadir A, Luong N, Ni X, Nitz S, Ookhin H, Orlov A, Payne A, Pearl R, Pedowitz N, Peng S, Perry B, Pulido I, Rawal D, Reid L, Retchin M, Richardson R, Ripka E, Robinson M, Robinson R, Rodriguez M, Roper G, Rosales R, Salim M, Scheen J, Schiffer C, Shamir Y, Shaqra A, Shaw C, Shertzer O, Singh S, Sjo P, Slater J, Souffront A, Stacey J, Gordon H, Starr T, Stewart H, Szommer T, Tanner W, Thomas V, Thompson W, Tierney J, Tivon B, Tomlinson C, Vargo T, Villalo F, von Delft A, von Delft F, Walsh M, Sije W, Wang S, Wang Y, Waring M, White K, Wild C, Wilen C, Williams E, Williams M, Winokan M, Wright N, Xavier M, Yap J, Zhang I, Zhu J, Zwaka T, Robinson M, London N, Resnick E, Zaidmann D, Gehrtz P, Reddi R, Gabizon R, Barr H, Duberstein S, Zidane H, Shurrush K, Cohen G, Solmesky L, Lee A, Jajack A, Cvitkovic M, Pan J, Pai R, Ripka E, Nguyen L, Shafeev M, Matviiuk T, Michurin O, Chernyshenko E, Bilenko V, Kinakh S, Logvinenko I, Melnykov K, Huliak V, Tsurupa I, Gorichko M, Shaikh A, Pinjari J, Swamy V, Pingle M, BVNBS S, Aimon A, von Delft F, Fearon D, Tomlinson C, Balcomb B, Lithgo R, Aschenbrenner J, Dunnett L, Douangamath A, Dias A, Powell A, Neto J, Skyner R, Thompson W, Gorrie-Stone T, Walsh M, Owen C, Lukacik P, Strain-Damerell C, Mikolajek H, Horrell S, Marples P, Koekemoer L, Krojer T, Fairhead M, MacLean E, Thompson A, Wild C, Smilova M, Wright N, von Delft A, Gileadi C, Rangel V, Schofield C, Salah E, Malla T, Tumber A, John T, Vakonakis I, Kantsadi A, Zitzmann N, Brun J, Kiappes J, Hill M, Witt K, Alonzi D, Makower L, Varghese F, Overheul G, Miesen P, van Rij R, Jansen J, Smeets B, Tomásio S, Weatherall C, Vaschetto M, Macdonald H, Chodera J, Rufa D, Wittmann M, Boby M, Henry M, Glass W, Eastman P, Coffland J, Dotson D, Griffen E, McCorkindale W, Morris A, Glen R, Cole J, Foster R, Foster H, Calmiano M, Tennant R, Heer J, Shi J, Jnoff E, Hurley M, Lefker B, Robinson R, Giroud C, Bennett J, Fedorov O, Reid P, Morwitzer M, Cox L, Morris G, Ferla M, Moustakas D, Dudgeon T, Pšenák V, Kovar B, Voelz V, Carbery A, Contini A, Clyde A, Ben-Shmuel A, Sittner A, Politi B, Vitner E, David E, Tamir H, Achdout H, Levy H, Glinert I, Paran N, Erez N, Puni R, Melamed S, Weiss S, Israely T, Yahalom-Ronen Y, Smalley A, Oleinikovas V, Spencer J, Kenny P, Ward W, Cattermole E, Ferrins L, Eyermann C, Milne B, Godoy A, Noske G, Oliva G, Fernandes R, Nakamura A, Gawriljuk V, White K, McGovern B, Rosales R, García-Sastre A, Carney D, Chang E, Saikatendu K, Vangeel L, Neyts J, Donckers K, Jochmans D, De Jonghe S, Bowman G, Borden B, Singh S, Volkamer A, Rodriguez-Guerra J, Fate G, Hart S, Saar K, Perry B, Fraisse L, Sjö P, Boulet P, Laghnimi-Hahn S, Mowbray C, Reid L, Rees P, Huang Q, Zvornicanin S, Shaqra A, Yilmaz N, Schiffer C, Zhang I, Pulido I, Taylor J, Croll T, Brewitz L, Kang L, La V, Haneef A, Minh D, Filep M, Scheen J, Kaminow B, Arbon R, Payne A, Schaller D. Enabling equitable and affordable access to novel therapeutics for pandemic preparedness and response via creative intellectual property agreements. Wellcome Open Research 2024, 9: 374. PMID: 39184131, PMCID: PMC11342024, DOI: 10.12688/wellcomeopenres.22645.1.Peer-Reviewed Original ResearchCitationsAltmetricEnhanced eMAGE applied to identify genetic factors of nuclear hormone receptor dysfunction via combinatorial gene editing
Ciaccia P, Liang Z, Schweitzer A, Metzner E, Isaacs F. Enhanced eMAGE applied to identify genetic factors of nuclear hormone receptor dysfunction via combinatorial gene editing. Nature Communications 2024, 15: 5218. PMID: 38890276, PMCID: PMC11189492, DOI: 10.1038/s41467-024-49365-z.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor Beckman Young Investigator Award
09/01/2012National AwardArnold and Mabel Beckman FoundationDetailsUnited Stateshonor Rising Young Stars of Science
01/01/2008UnknownGenome Technology MagazineDetailsUnited States
News & Links
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News
- June 09, 2025Source: Yale News
Yale Genome Engineers Expand the Reach and Precision of Human Gene Editing
- February 06, 2025Source: Yale News
Yale Scientists Recode the Genome for Programmable Synthetic Proteins
- February 05, 2025Source: Nature
Engineering a genomically recoded organism with one stop codon
- October 12, 2022
Yale Cancer Center Members Receive Faculty Innovation Awards
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Locations
Science Hill
Academic Office
Kline Biology Tower
219 Prospect Street, Ste KBT 802
New Haven, CT 06511
Appointments
203.432.3783West Campus
Lab
100 West Campus Drive, Ste B-31, #209
Orange, CT 06477