2021
Urine and Tissue Bacterial Loads Correlate With Voiding Behaviors in a Murine Urinary Tract Infection Model
Zhu K, Hill WG, Li F, Shi B, Chai TC. Urine and Tissue Bacterial Loads Correlate With Voiding Behaviors in a Murine Urinary Tract Infection Model. Urology 2021, 154: 344.e1-344.e7. PMID: 34010680, DOI: 10.1016/j.urology.2021.05.009.Peer-Reviewed Original ResearchConceptsUrinary tract infectionKidney bacterial loadsBacterial loadVoiding behaviorChronic urinary tract infectionMurine urinary tract infection modelSpot assayTissue bacterial loadUrinary tract infection modelChronic pyelonephritisUrinary frequencyBladder capacityTract infectionsChronic cystitisUrine cultureInfected miceFemale miceHistology changesMurine modelInfected bladdersDays postinfectionTissue fibrosisPolyuriaInfection modelE. coli UTI89Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3
Yuan Q, Basit A, Liang W, Qu R, Luan Y, Ren C, Li A, Xu X, Liu X, Yang C, Kuo A, Pierce R, Zhang L, Turk B, Hu X, Li F, Cui W, Li R, Huang D, Mo L, Sessa WC, Lee PJ, Kluger Y, Su B, Tang W, He J, Wu D. Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3. Science Translational Medicine 2021, 13 PMID: 33910977, PMCID: PMC8466683, DOI: 10.1126/scitranslmed.abc2499.Peer-Reviewed Original ResearchConceptsAcute lung injuryLung injuryMyeloid cellsLung transplantation recipientsMouse ALI modelPulmonary barrier functionTransplantation recipientsALI modelReactive oxygen species formationPharmacological interventionsPazopanibOxygen species formationVasculature integrityEpithelial cell survivalHigh mortalityMitogen-activated protein kinase kinase kinase 2Barrier functionGenetic inactivationInjuryCell survivalMortalityProtein kinase kinase kinase 2MAP3K3Kinase 2Manifestations
2020
Early Increased Urinary IL-2 and IL-10 Levels Were Associated With Development of Chronic UTI in a Murine Model
Zhu K, Hill WG, Li F, Shi B, Chai TC. Early Increased Urinary IL-2 and IL-10 Levels Were Associated With Development of Chronic UTI in a Murine Model. Urology 2020, 141: 188.e1-188.e6. PMID: 32201154, DOI: 10.1016/j.urology.2020.03.015.Peer-Reviewed Original ResearchConceptsChronic urinary tract infectionUrinary tract infectionCytokines/chemokinesIL-2IL-10Enzyme-linked immunosorbent assayBacterial loadInflammatory cytokines/chemokinesTissue bacterial loadUrinary IL-2IL-10 levelsDays post infectionUTI susceptibilityTract infectionsMurine modelUTI infectionsPost infectionVoiding behaviorChemokinesMiceImmunosorbent assayResistant groupInfectionSignificant differencesDpi
2018
Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice
Hu Y, Peng J, Li F, Wong FS, Wen L. Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice. Scientific Reports 2018, 8: 15451. PMID: 30337545, PMCID: PMC6193974, DOI: 10.1038/s41598-018-33571-z.Peer-Reviewed Original ResearchConceptsType 1 diabetesWeeks of ageGut microbiotaNOD miceVaginal microbiotaAuto-reactive T cellsNon-obese diabetic (NOD) micePeripheral blood mononuclear cellsInsulin-producing beta cellsFemale NOD miceProgressive autoimmune diseaseOnset of diabetesBlood mononuclear cellsDifferent mucosal sitesT1D developmentDiabetes onsetMucosal sitesDiabetes developmentDiabetic miceAutoimmune diseasesComposition of microbiotaMononuclear cellsT cellsMucosal microbiotaAdult mice
2007
A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract
Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L. A Novel Pathway That Regulates Inflammatory Disease in the Respiratory Tract. The Journal Of Immunology 2007, 178: 3846-3855. PMID: 17339484, DOI: 10.4049/jimmunol.178.6.3846.Peer-Reviewed Original ResearchConceptsAirway inflammationInflammatory diseasesRespiratory tractTh2-induced airway inflammationChronic airway inflammatory diseaseLymphocyte-deficient miceState of immunosuppressionAcute airway inflammationAirway inflammatory diseasesEffector Th cellsTh2 cells resultsAirway hyperresponsivenessInflammation wanesTh2 modelEffector Th1Respiratory illnessTh cellsInhalational exposureInflammationInhibitory effectSuch diseasesDiseaseStriking inhibitionTh1Localized treatment