2020
F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis
Belsky JB, Filbin MR, Rivers EP, Bobbitt KR, Jaehne AK, Wisnik CA, Maciejewski KR, Li F, Morris DC. F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis. Biomarkers 2020, 25: 391-396. PMID: 32421363, DOI: 10.1080/1354750x.2020.1771419.Peer-Reviewed Original ResearchConceptsIntensive care unitEmergency departmentQSOFA scoreIllness severityPlasma levelsThymosin beta 4Quick Sequential Organ Failure Assessment (qSOFA) scoreSequential Organ Failure Assessment scoreIntensive care unit admissionOrgan Failure Assessment scoreCare unit admissionPositive urine cultureSymptoms of sepsisSystemic inflammatory syndromeDiagnosis of sepsisEmergency department patientsSignificant outcome measureBeta 4Unit admissionICU admissionInflammatory syndromeDepartment patientsSeptic shockCare unitED patients
2018
Using System Inflammatory Response Syndrome as an Easy-to-Implement, Sustainable, and Automated Tool for All-Cause Deterioration Among Medical Inpatients
Fogerty RL, Sussman LS, Kenyon K, Li F, Sukumar N, Kliger AS, Acker K, Sankey C. Using System Inflammatory Response Syndrome as an Easy-to-Implement, Sustainable, and Automated Tool for All-Cause Deterioration Among Medical Inpatients. Journal Of Patient Safety 2018, Publish Ahead of Print: &na;. PMID: 29369071, DOI: 10.1097/pts.0000000000000463.Peer-Reviewed Original ResearchConceptsDefinition of sepsisClinical deteriorationMedical inpatientsAdult inpatientsSystemic inflammatory response syndrome criteriaElectronic health record toolsInflammatory response syndromeAcademic medical centerSyndrome criteriaResponse syndromeClinical benefitMedical CenterHigh riskMinimal additional resourcesInpatientsSIRSSepsisPatientsIntervention toolSpectrum disorderDeteriorationAdmissionSyndrome
2014
Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis
Levit O, Bhandari V, Li FY, Shabanova V, Gallagher PG, Bizzarro MJ. Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis. The Pediatric Infectious Disease Journal 2014, 33: 143-146. PMID: 24418836, PMCID: PMC3917323, DOI: 10.1097/inf.0000000000000024.Peer-Reviewed Original ResearchConceptsLate-onset sepsisLow birth weight infantsBirth weight infantsIndependent risk factorLaboratory factorsWeight infantsVLBW infantsRisk factorsCases of LOSEpisodes of LOSRisk of LOSFungal LOSNeonatal intensive care unitMultivariate logistic regression analysisSepsis-related deathsIntensive care unitOnset of illnessSepsis-associated mortalityGram-positive infectionsLogistic regression analysisOnset of diseasePresentation of illnessComposite risk profileLaboratory signsNecrotizing enterocolitisThe Temporal Kinetics of Circulating Angiopoietin Levels in Children With Sepsis
Giuliano JS, Tran K, Li FY, Shabanova V, Tala JA, Bhandari V. The Temporal Kinetics of Circulating Angiopoietin Levels in Children With Sepsis. Pediatric Critical Care Medicine 2014, 15: e1-e8. PMID: 24141659, PMCID: PMC3947338, DOI: 10.1097/pcc.0b013e3182a553bb.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAngiopoietin-1Angiopoietin-2BiomarkersCase-Control StudiesChildChild, PreschoolFemaleHumansIntensive Care Units, PediatricLength of StayMalePredictive Value of TestsProspective StudiesSepsisSeverity of Illness IndexShock, SepticSystemic Inflammatory Response SyndromeTime FactorsConceptsSevere sepsis/shockSepsis/shockSystemic inflammatory response syndrome/sepsisPediatric patientsShock groupAngiopoietin-2Day 2Angiopoietin-1Days of illnessHours of admissionIll pediatric patientsInflammatory response syndromeRisk stratification scoresProspective observational studyCritical care physiciansVascular growth factorsEnzyme-linked immunosorbentAngiopoietin levelsPICU lengthPICU patientsSevere sepsisSepsis severityResponse syndromeStratification scoresCare physicians
2013
Neutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis
Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz RA, Rinder HM, Bhandari V. Neutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis. American Journal Of Perinatology 2013, 31: 021-030. PMID: 23456906, DOI: 10.1055/s-0033-1334453.Peer-Reviewed Original ResearchConceptsCulture-proven sepsisClinical sepsisNeutrophil CD64CD64 indexNeonatal sepsisHematologic criteriaSingle-centre neonatal intensive care unitEarly-onset clinical sepsisNeonatal intensive care unitNeutrophil CD64 indexProspective observational cohortAbsolute neutrophil countNormal birth weightIntensive care unitAbsolute band countNegative predictive valueAdditional markersSepsis evaluationNeutrophil countObservational cohortCare unitBirth weightHematologic parametersSepsisCD64
2012
Neutrophil CD64 as a Diagnostic Marker in Neonatal Sepsis
Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz R, Rinder HM, Bhandari V. Neutrophil CD64 as a Diagnostic Marker in Neonatal Sepsis. The Pediatric Infectious Disease Journal 2012, 31: 777-781. PMID: 22481422, PMCID: PMC3375383, DOI: 10.1097/inf.0b013e318256fb07.Peer-Reviewed Original Research