2017
Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents
Tricò D, Prinsen H, Giannini C, de Graaf R, Juchem C, Li F, Caprio S, Santoro N, Herzog RI. Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2017, 102: 2473-2481. PMID: 28482070, PMCID: PMC5505187, DOI: 10.1210/jc.2017-00475.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmino Acids, Branched-ChainBiomarkersBlood GlucoseChildCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestGlycemic IndexHumansHydroxybutyratesInsulin ResistanceLinear ModelsLongitudinal StudiesMaleMultivariate AnalysisObesityPredictive Value of TestsReference ValuesRisk AssessmentConceptsOral glucose tolerance testBranched-chain amino acidsGlycemic controlInsulin resistanceΑ-hydroxybutyrateGlucose toleranceInsulin sensitivityParameters of IRBody mass index z-scoreType 2 diabetes mellitusEarly metabolic featuresChain amino acid levelsTraditional risk factorsPediatric obesity clinicGlucose tolerance testElevated baseline concentrationsIndex z-scoreType 2 diabetesReduced insulin sensitivityDiabetes mellitusObesity clinicNondiabetic adolescentsProgressive worseningDisposition indexGlucose control
2016
Psychosocial predictors and moderators of weight management programme outcomes in ethnically diverse obese youth
Taylor JH, Xu Y, Li F, Shaw M, Dziura J, Caprio S, Tamborlane WV, Nowicka P, Savoye M. Psychosocial predictors and moderators of weight management programme outcomes in ethnically diverse obese youth. Pediatric Obesity 2016, 12: 453-461. PMID: 27384496, PMCID: PMC5568975, DOI: 10.1111/ijpo.12165.Peer-Reviewed Original ResearchConceptsClinic careObese youthOutpatient clinic careAbnormal glucose toleranceObesity treatment outcomesObesity intervention programFamily functioningLifestyle interventionGlucose toleranceChildhood obesityLifestyle programTreatment outcomesPsychosocial predictorsIdentification of factorsIntervention programsIntervention outcomesOutcomesPoor family functioningTreatment effectsHigh anxietyBaselineCareMonthsIntervention
2014
Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, DePourcq F, Kim G, Tamborlane WV. Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care 2014, 37: 317-324. PMID: 24062325, PMCID: PMC3898759, DOI: 10.2337/dc13-1571.Peer-Reviewed Original ResearchConceptsStandard of careClinical careBlood glucoseObese adolescentsObese youthOral glucose tolerance test glucoseIntensive lifestyle modificationDiabetes Prevention ProgramStandard clinical careInsulin sensitivity indexHealthy lifestyle programType 2 diabetesRisk of T2DChildhood obesity epidemicΒ-cell dysfunctionLifestyle modificationControlled TrialsOGTT glucosePrimary outcomeGlucose toleranceInsulin resistanceLifestyle programAnthropometric assessmentEarly abnormalitiesGlucose levels