2024
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
Boisserand L, Geraldo L, Bouchart J, Kamouh M, Lee S, Sanganahalli B, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez S, Singhabahu R, Robinson M, Askenase M, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing L, Benveniste H, Hyder F, Thomas J. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. Journal Of Experimental Medicine 2024, 221: e20221983. PMID: 38442272, PMCID: PMC10913814, DOI: 10.1084/jem.20221983.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factor-CDeep cervical lymph nodesCentral nervous systemEffect of vascular endothelial growth factor-CMeningeal lymphatic vesselsAmeliorated motor performanceCervical lymph nodesIschemic strokeVEGF-C overexpressionIncreased BDNF signalingAcute ischemic strokeBrain cellsIncreased CSF drainageIschemic stroke outcomesModel of ischemic strokeMouse model of ischemic strokeImmune surveillanceCSF drainageLymph nodesFluid drainageNucleus RNA sequencingLymphatic growthLymphatic drainageMouse modelBDNF signalingMultimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2023
Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury
Mihailovic J, Sanganahalli B, Hyder F, Chitturi J, Elkabes S, Heary R, Kannurpatti S. Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury. Neuroscience Letters 2023, 820: 137607. PMID: 38141752, PMCID: PMC10797561, DOI: 10.1016/j.neulet.2023.137607.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCervical spinal cord injuryDiffusion tensor imagingCord injurySpinal cordCervical spinal cordState functional connectivitySpinal cord samplesSpinal cord diffusion tensor imagingMagnetic resonance imagingBrain functional MRIInjury epicenterSpinal reorganizationPost-SCINeuroplastic changesCord samplesCortical sensoryRat modelTraumatic injuryMD changeMotor networkNervous systemResonance imagingSingle-subject levelFunctional MRIA multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke
Lyden P, Diniz M, Bosetti F, Lamb J, Nagarkatti K, Rogatko A, Kim S, Cabeen R, Koenig J, Akhter K, Arbab A, Avery B, Beatty H, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman A, Hyder F, Imai T, Johnson C, Khan M, Kamat P, Karuppagounder S, Kumskova M, Mihailovic J, Mandeville J, Morais A, Patel R, Sanganahalli B, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez S, Aronowski J, Ayata C, Chauhan A, Leira E, Hess D, Koehler R, McCullough L, Sansing L. A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Science Translational Medicine 2023, 15: eadg8656. PMID: 37729432, DOI: 10.1126/scitranslmed.adg8656.Peer-Reviewed Original ResearchConceptsPreclinical assessmentFocal cerebral ischemic insultAcute ischemic strokeCerebral ischemic insultLarge clinical trialsDiet-induced obesityNew clinical interventionsIntravascular thrombectomyIschemic strokeStroke treatmentHypertensive ratsIschemic insultBlinded assessmentClinical trialsYoung miceTreatment candidatesExclusion criteriaAnimal modelsYoung ratsFutile interventionsPreclinical trialsClinical interventionsFutility boundariesMiceDisease areasSpatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic wasteA consensus protocol for functional connectivity analysis in the rat brain
Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière D, Blockx I, Bortel A, Broadwater M, Cardoso B, Célestine M, Chavez-Negrete J, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes F, Fowler C, Fuentes-Ibañez A, Garin C, Gelderman E, Golden C, Guo C, Henckens M, Hennessy L, Herman P, Hofwijks N, Horien C, Ionescu T, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee S, Lillywhite A, Liu Y, Liu Y, López -Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan M, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens D, Nava-Gomez L, Nonaka H, Ortiz J, Paasonen J, Peeters L, Pereira M, Perez P, Pompilus M, Prior M, Rakhmatullin R, Reimann H, Reinwald J, Del Rio R, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten T, Ryoke R, Sack M, Salvan P, Sanganahalli B, Schroeter A, Seewoo B, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith J, Smith C, Sobczak F, Stenroos P, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García M, Tudela R, van den Berg M, van der Marel K, van Hout A, Vertullo R, Vidal B, Vrooman R, Wang V, Wank I, Watson D, Yin T, Zhang Y, Zurbruegg S, Achard S, Alcauter S, Auer D, Barbier E, Baudewig J, Beckmann C, Beckmann N, Becq G, Blezer E, Bolbos R, Boretius S, Bouvard S, Budinger E, Buxbaum J, Cash D, Chapman V, Chuang K, Ciobanu L, Coolen B, Dalley J, Dhenain M, Dijkhuizen R, Esteban O, Faber C, Febo M, Feindel K, Forloni G, Fouquet J, Garza-Villarreal E, Gass N, Glennon J, Gozzi A, Gröhn O, Harkin A, Heerschap A, Helluy X, Herfert K, Heuser A, Homberg J, Houwing D, Hyder F, Ielacqua G, Jelescu I, Johansen-Berg H, Kaneko G, Kawashima R, Keilholz S, Keliris G, Kelly C, Kerskens C, Khokhar J, Kind P, Langlois J, Lerch J, López-Hidalgo M, Manahan-Vaughan D, Marchand F, Mars R, Marsella G, Micotti E, Muñoz-Moreno E, Near J, Niendorf T, Otte W, Pais-Roldán P, Pan W, Prado-Alcalá R, Quirarte G, Rodger J, Rosenow T, Sampaio-Baptista C, Sartorius A, Sawiak S, Scheenen T, Shemesh N, Shih Y, Shmuel A, Soria G, Stoop R, Thompson G, Till S, Todd N, Van Der Linden A, van der Toorn A, van Tilborg G, Vanhove C, Veltien A, Verhoye M, Wachsmuth L, Weber-Fahr W, Wenk P, Yu X, Zerbi V, Zhang N, Zhang B, Zimmer L, Devenyi G, Chakravarty M, Hess A. A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience 2023, 26: 673-681. PMID: 36973511, PMCID: PMC10493189, DOI: 10.1038/s41593-023-01286-8.Peer-Reviewed Original ResearchConcerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions
de Arce K, Ribic A, Chowdhury D, Watters K, Thompson G, Sanganahalli B, Lippard E, Rohlmann A, Strittmatter S, Missler M, Hyder F, Biederer T. Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions. Nature Communications 2023, 14: 459. PMID: 36709330, PMCID: PMC9884278, DOI: 10.1038/s41467-023-36042-w.Peer-Reviewed Original ResearchConceptsPrefrontal cortexDKO miceSynCAM 1Aberrant neuronal activityDendritic spine numberPrefrontal cortex synapsesSynapse organizersSynapse numberMature brainNeuronal activityKnockout miceSpine numberSynapse developmentCognitive functionTrans-synaptic complexesImmunoglobulin family membersMiceFamily membersSynapsesLRRTM1Behavioral domainsHippocampusCognitive tasksConcerted roleCortexDecreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.Peer-Reviewed Original ResearchConceptsThalamic neuronsAbsence seizuresSeizure onsetNeuronal firingConsciousness-impairing seizuresFemale rat modelLow-frequency electroencephalographic activityFunctional magnetic resonanceBehavioral arrestRat modelRhythmic firingTransient initial peakFiring increasesSeizuresNeuronal mechanismsElectroencephalographic activityNeuronsBrain state changesBrief episodesFiring decreasesInitial peakFiringMagnetic resonanceDistinct patternsOnsetEmbracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial
Morais A, Locascio J, Sansing L, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig J, Bosetti F, Lyden P, Ayata C, Bosetti F, Koenig J, Lyden P, Lamb J, Nagarkatti K, Hess D, Kamat P, Khan M, Dhandapani K, Arbab A, Siddiqui S, Smith C, Nisar M, Leira E, Chauhan A, Dhanesha N, Patel R, Kumskova M, Thedens D, Wang K, Ayata C, Morais A, Imai T, Qin T, Jin X, Erdogan T, Yu L, Mandeville J, Kimberly W, Whittier J, Lo E, Arai K, Van Leyen K, Sansing L, Hyder F, Mihailovic J, Sanganahalli B, Diaz-Perez S, Velazquez S, Beatty H, Johnson C, Herman A, Boisserand L, Immakavar E, Koehler R, Dawson T, Dawson V, Shi Y, Avery B, Lannon S, Bibic A, Akhter K, Karuppagounder S, Aronowski J, McCullough L, Obertas L, Goh A, Huang S, Chauhan A. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke 2023, 54: 620-631. PMID: 36601951, PMCID: PMC9870939, DOI: 10.1161/strokeaha.122.040638.Peer-Reviewed Original ResearchConceptsTotal anesthesia durationAnesthesia durationIndependent predictorsMultivariable analysisClinical trialsTransient focal cerebral ischemiaFocal cerebral ischemiaCerebral blood flowLaser Doppler flowCentralized randomizationModified intentionTreat populationExperimental strokeCerebral ischemiaDoppler flowRodent modelsMCAOBlood flowNetwork trialFlow dropPreclinical trialsMouse cohortsStudy designTrialsTrial onset
2022
Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography
Mishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.Peer-Reviewed Original ResearchConceptsProtein nanoparticlesParamagnetic iron oxide nanoparticlesIron oxide nanoparticlesMagnetic resonance imaging (MRI) contrastRelaxivity ratioOxide nanoparticlesRapid renal clearanceNanoparticlesMRI propertiesImaging contrastMRI contrastCitric acidNeuroscience applicationsFluorescent dyeBlood biochemical assaysUnambiguous detectionRelaxivityCerebral angiographyDyePlatformMajor blood vesselsBiochemical assaysTechnologyBrain capillariesFluorescence angiographyMR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver
Santana J, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald L, Boustani A, Walsh J, Kucukkaya A, Malpani R, Madoff D, Goldberg S, Ahmed M, Joshi N, Coman D, Chapiro J. MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 395-403.e5. PMID: 36423815, PMCID: PMC11042914, DOI: 10.1016/j.jvir.2022.11.013.Peer-Reviewed Original ResearchConceptsImmune responseT1-weighted MRPrussian blue stainingRadiofrequency ablationRF ablationC57BL/6 wild-type miceMR imagingDose-escalation studyLocal immune responseMass cytometryWild-type miceRadiological-pathological correlationBlue stainingT1-weighted MR imagingHepatic radiofrequency ablationCD68 antibodyUntreated lobeVivo doseHepatic RF ablationVivo macrophagesMacrophagesMiceMR imaging scannerCoagulation areaCD68Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type
O’Connor D, Mandino F, Shen X, Horien C, Ge X, Herman P, Hyder F, Crair M, Papademetris X, Lake E, Constable. Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type. NeuroImage 2022, 264: 119735. PMID: 36347441, PMCID: PMC9808917, DOI: 10.1016/j.neuroimage.2022.119735.Peer-Reviewed Original Research
2016
Metabolic demands of neural-hemodynamic associated and disassociated areas in brain
Sanganahalli BG, Herman P, Rothman DL, Blumenfeld H, Hyder F. Metabolic demands of neural-hemodynamic associated and disassociated areas in brain. Cerebrovascular And Brain Metabolism Reviews 2016, 36: 1695-1707. PMID: 27562867, PMCID: PMC5076793, DOI: 10.1177/0271678x16664531.Peer-Reviewed Original ResearchConceptsVentral posterolateral thalamic nucleusFunctional magnetic resonance imagingMulti-unit activityLocal field potentialsMetabolic demandsPosterolateral thalamic nucleusBlood oxygenation level-dependent (BOLD) responseSensory-evoked responsesCortical local field potentialsThalamic local field potentialsMagnetic resonance imagingLevel-dependent responsesSimilar metabolic demandThalamic nucleiForelimb cortexBlood flowBlood volumeCBV responseResonance imagingLatency differenceHemodynamicsBOLD signalOxidative metabolismDifferent metabolic demandsField potentialsTowards longitudinal mapping of extracellular pH in gliomas
Huang Y, Coman D, Herman P, Rao JU, Maritim S, Hyder F. Towards longitudinal mapping of extracellular pH in gliomas. NMR In Biomedicine 2016, 29: 1364-1372. PMID: 27472471, PMCID: PMC5035200, DOI: 10.1002/nbm.3578.Peer-Reviewed Original ResearchConceptsSurgical interventionPlasma concentrationsU87 brain tumorsPreclinical modelsRenal clearanceSame subjectsTumor assessmentBrain tumorsProbe doseTherapeutic monitoringTranslational valueTumor characterizationLongitudinal scansChemical shift imaging techniqueThulium ionsMolecular imagingParamagnetic probesInterventionScansImaging techniquesSubjectsNon-exchangeable protonsChapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI
Shu CY, Sanganahalli BG, Coman D, Herman P, Hyder F. Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI. Progress In Brain Research 2016, 225: 99-122. PMID: 27130413, DOI: 10.1016/bs.pbr.2016.02.003.Peer-Reviewed Original ResearchConceptsNeurovascular couplingFunctional MRINeuronal activityBlood oxygenation level-dependent (BOLD) signalFunctional brain activationLevel-dependent signalNeurometabolic couplingEffective therapyBlood flowNeuroimaging toolsHealth conditionsPowerful neuroimaging toolBrain activationBOLD signalNeural activityBOLD contrastMetabolic demandsOxygen consumptionDependent signalsTherapyMicrovesselsMRIActivityBiomarkersImaging the intratumoral–peritumoral extracellular pH gradient of gliomas
Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas. NMR In Biomedicine 2016, 29: 309-319. PMID: 26752688, PMCID: PMC4769673, DOI: 10.1002/nbm.3466.Peer-Reviewed Original ResearchConceptsRG2 tumorsTumor typesKi-67-positive cellsCancer therapeutic responseAcidic pHeTherapeutic responseRat brainPositive cellsSolid tumorsTumor cell invasionTumor borderTumorsPeritumoral regionNormal tissuesCell invasionTumor pHeP-MRSCancer imagingNeutral intracellularImagingPreclinical applicationsInfusionTherapy
2015
Quantitative β mapping for calibrated fMRI
Shu CY, Sanganahalli BG, Coman D, Herman P, Rothman DL, Hyder F. Quantitative β mapping for calibrated fMRI. NeuroImage 2015, 126: 219-228. PMID: 26619788, PMCID: PMC4733593, DOI: 10.1016/j.neuroimage.2015.11.042.Peer-Reviewed Original ResearchDecreased Subcortical Cholinergic Arousal in Focal Seizures
Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Decreased Subcortical Cholinergic Arousal in Focal Seizures. Neuron 2015, 85: 561-572. PMID: 25654258, PMCID: PMC4319118, DOI: 10.1016/j.neuron.2014.12.058.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresFocal temporal lobe seizuresReduced cholinergic neurotransmissionBilateral temporal lobesLoss of consciousnessPedunculopontine tegmental nucleusQuality of lifeBrainstem arousal systemsFunctional magnetic resonanceSeizure spreadCholinergic neuronsImpaired consciousnessFocal seizuresBasal forebrainAnterior hypothalamusCholinergic neurotransmissionTegmental nucleusLateral septumCortical functionRodent modelsTemporal lobeSubcortical regionsSeizuresImpair consciousnessSubcortical arousal
2014
Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior
Shulman RG, Hyder F, Rothman DL. Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1721-1735. PMID: 25160670, PMCID: PMC4269754, DOI: 10.1038/jcbfm.2014.145.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingNeuronal activityMental moduleObservable behaviorBrain activityDistinct psychological mechanismsResonance imagingBaseline neuronal activityPositron emission tomography (PET) imagingEmission Tomography ImagingPsychological mechanismsMental processesFunctional neuroimagingBrain supportAwake humansAlternative empirical modelsNeurophysiological parametersBaseline activityTomography imagingTheoretical assumptionsSensory systemsIncremental signalNeuroimagingElectrical recordingsCaloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity
Lin AL, Coman D, Jiang L, Rothman DL, Hyder F. Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1440-1443. PMID: 24984898, PMCID: PMC4158670, DOI: 10.1038/jcbfm.2014.114.Peer-Reviewed Original ResearchConceptsOld CR ratsNeuronal activityYoung controlsCR ratsCaloric restriction (CR) prolongs lifespanHealthy agingNeuronal glucose oxidationBrain mitochondrial functionNeuronal energy productionMitochondrial functionAge-related declineNeurotransmitter cyclingOlder controlsNeurotransmission ratesBrain physiologyRatsGlucose oxidationProlong lifespanVivo nuclear magnetic resonance (NMR) spectroscopyMagnetic resonance spectroscopyDetrimental effectsAgingControl