The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation
Caron E, Vincent K, Fortier M, Laverdure J, Bramoullé A, Hardy M, Voisin G, Roux P, Lemieux S, Thibault P, Perreault C. The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation. Molecular Systems Biology 2011, 7: msb201168. PMID: 21952136, PMCID: PMC3202804, DOI: 10.1038/msb.2011.68.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell Line, TumorCell MembraneGene Expression ProfilingHigh-Throughput Screening AssaysHistocompatibility Antigens Class IImmunityMajor Histocompatibility ComplexMass SpectrometryMetabolic Networks and PathwaysMiceOligonucleotide Array Sequence AnalysisPeptidesProteomicsSignal TransductionSirolimusSystems BiologyTandem Mass SpectrometryTOR Serine-Threonine KinasesConceptsCell surfaceMass spectrometry-based approachSystems-level evidenceSelf/non-self discriminationCellular regulationPredictive biologyCellular metabolic activityCellular metabolismNon-self discriminationRapamycin resultsMammalian targetMHC IBiochemical networksCD8 T lymphocytesSystems immunologyMajor histocompatibility complex (MHC) class I moleculesMetabolic eventsExtrinsic factorsMetabolic activityIntegrative viewClass I moleculesImmunotherapeutic interventionsT lymphocytesEssence of selfSystem-level perspective