2015
Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers
Esterhuyse M, Weiner J, Caron E, Loxton A, Iannaccone M, Wagman C, Saikali P, Stanley K, Wolski W, Mollenkopf H, Schick M, Aebersold R, Linhart H, Walzl G, Kaufmann S. Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers. MBio 2015, 6: 10.1128/mbio.01187-15. PMID: 26374119, PMCID: PMC4600108, DOI: 10.1128/mbio.01187-15.Peer-Reviewed Original ResearchConceptsTB patientsPilot studyActive tuberculosis diseaseLarge-scale studiesSpread of TBLTBI controlLTBI participantsTuberculosis infectionTuberculosis diseaseDisease progressionHealthy controlsPrognostic biomarkerImmune responseBiologic mechanismsHealthy individualsPatientsHost responseInfected individualsBetter careInfectious diseasesMycobacterium tuberculosisSmall sample sizeBiomarker developmentRegulation of functionDNA methylation
2013
The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans
Vachon-Presseau E, Roy M, Martel M, Caron E, Marin M, Chen J, Albouy G, Plante I, Sullivan M, Lupien S, Rainville P. The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans. Brain 2013, 136: 815-827. PMID: 23436504, DOI: 10.1093/brain/aws371.Peer-Reviewed Original ResearchConceptsChronic back painChronic painHippocampal volumeBack painControl subjectsParahippocampal gyrusPain-evoked activityPersistent pain statesAnterior parahippocampal gyrusHealthy control subjectsSmaller hippocampal volumesChronic pain intensityEndocrine stress responsePain statesPain intensityPain responseBasal cortisolPainHippocampal structureCortisol levelsMaladaptive physiological responsesHigher cortisolHippocampal complexConsecutive daysPatients