2019
Polymicrobial Nature of Tick-Borne Diseases
Sanchez-Vicente S, Tagliafierro T, Coleman J, Benach J, Tokarz R, Azad A, Fikrig E, Munderloh U, Telford S. Polymicrobial Nature of Tick-Borne Diseases. MBio 2019, 10: e02055-19. PMID: 31506314, PMCID: PMC6737246, DOI: 10.1128/mbio.02055-19.Peer-Reviewed Original ResearchConceptsPolymicrobial infectionsClinical spectrumTick-borne diseasesFatal infectionPowassan virusDisproportionate incidenceTick-borne diseaseDifficult diagnosisNew pathogensNew agentsPolymicrobial natureDisease severityInfectionDiseaseLyme diseasePrevalent pathogenBorreliaHigh rateIncidenceDiagnosisSeverityRickettsiaTick vectorVirusClimate change
2012
SERUM ANTIBODIES TO WHOLE-CELL AND RECOMBINANT ANTIGENS OF BORRELIA BURGDORFERI IN COTTONTAIL RABBITS
Magnarelli LA, Norris SJ, Fikrig E. SERUM ANTIBODIES TO WHOLE-CELL AND RECOMBINANT ANTIGENS OF BORRELIA BURGDORFERI IN COTTONTAIL RABBITS. Journal Of Wildlife Diseases 2012, 48: 12-20. PMID: 22247369, PMCID: PMC3261588, DOI: 10.7589/0090-3558-48.1.12.Peer-Reviewed Original Research
2001
Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis
Magnarelli LA, Levy SA, Ijdo JW, Wu C, Padula SJ, Fikrig E. Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis. Journal Of Medical Microbiology 2001, 50: 889-895. PMID: 11599738, DOI: 10.1099/0022-1317-50-10-889.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayWhole cell antigenRecombinant antigensB. burgdorferiNon-vaccinated dogsPolyvalent enzyme-linked immunosorbent assaysCanine borreliosisTick-infested areasTotal immunoglobulinWhole-cell B. burgdorferiAntibody titresBorrelia burgdorferi sensu strictoVaccinated dogsJoint disordersImmune responseBurgdorferi sensu strictoAntigenImmunosorbent assaySerumDogsNatural infectionReactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis.
Magnarelli LA, Ijdo JW, Van Andel AE, Wu C, Oliver JH, Fikrig E. Reactivity of serum samples of dogs and horses tested by use of class-specific recombinant-based enzyme-linked immunosorbent assays for detection of granulocytic ehrlichiosis. American Journal Of Veterinary Research 2001, 62: 1365-9. PMID: 11560261, DOI: 10.2460/ajvr.2001.62.1365.Peer-Reviewed Original ResearchConceptsIgG antibodiesSerum samplesHGE agentGranulocytic ehrlichiosisClient-owned dogsDog serum samplesHuman granulocytic ehrlichiosis (HGE) agentEnzyme-linked immunosorbentPositive resultsWestern blot analysisTick-infested areasEhrlichia phagocytophila genogroupTotal immunoglobulinHorse serum samplesPromyelocytic leukemia cellsClinical relevanceHuman promyelocytic leukemia cellsProtein antigensIgMELISADogsLeukemia cellsAntibodiesBlot analysisAntigen
1997
Antibodies to Ehrlichia equi in dogs from the northeastern United States.
Magnarelli L, IJdo J, Anderson J, Madigan J, Dumler J, Fikrig E. Antibodies to Ehrlichia equi in dogs from the northeastern United States. Journal Of The American Veterinary Medical Association 1997, 211: 1134-7. PMID: 9364226, DOI: 10.2460/javma.1997.211.09.1134.Peer-Reviewed Original ResearchConceptsE equiIndirect fluorescent antibodyWestern blot analysisSerologic testing methodsFluorescent antibodyBlot analysisTick-infested areasSeropositive dogsIll dogsMarked leukopeniaNormal dogsSubclinical infectionSerologic analysisEtiologic agentLaboratory diagnosisEnd pointGranulocytic ehrlichiosisEhrlichia equiDogsAntibodiesHuman isolatesBorrelia burgdorferiDog serumMultiple pathogensEhrlichiosis