2002
Salp15, an Ixodes scapularis Salivary Protein, Inhibits CD4+ T Cell Activation
Anguita J, Ramamoorthi N, Hovius JW, Das S, Thomas V, Persinski R, Conze D, Askenase PW, Rincón M, Kantor FS, Fikrig E. Salp15, an Ixodes scapularis Salivary Protein, Inhibits CD4+ T Cell Activation. Immunity 2002, 16: 849-859. PMID: 12121666, DOI: 10.1016/s1074-7613(02)00325-4.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCalcium SignalingCD4-Positive T-LymphocytesCell DivisionDrosophilaFemaleInterleukin-2IxodesLymphocyte ActivationMiceMice, Inbred BALB CMolecular Sequence DataRabbitsRatsReceptors, Antigen, T-CellReceptors, Interleukin-2Salivary Proteins and PeptidesConceptsT cell activationVector-host interactionsI. scapularis salivaCell activationMolecular basisFunctional importanceTCR ligationSalp15ProteinSalivary proteinsTick salivaCalcium fluxIxodes scapularis salivaActivationArthropodsRepressionImmune responseLow productionPleiotropic propertiesHostInhibits CD4T cell-mediated immune responsesVivo
1993
Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse
de Souza MS, Smith AL, Beck DS, Terwilliger GA, Fikrig E, Barthold SW. Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse. Infection And Immunity 1993, 61: 1814-1822. PMID: 8478071, PMCID: PMC280770, DOI: 10.1128/iai.61.5.1814-1822.1993.Peer-Reviewed Original ResearchConceptsT cell responsesDelayed-type hypersensitivity responseVigorous T cell responseRecipient C3H miceCell-mediated responsesAntigen-specific proliferationBorrelia burgdorferi infectionB cell mitogensAntigen-specific assaysLaboratory miceAdoptive transferImmune dysfunctionHypersensitivity responseResistant miceLymphocyte proliferationLymphoid organsBurgdorferi infectionC3H miceInterleukin-2Prostaglandin productionB cellsDiminished numberLyme borreliosisImpaired proliferationLong-term studies