2012
Anaplasma phagocytophilum Outer Membrane Protein A Interacts with Sialylated Glycoproteins To Promote Infection of Mammalian Host Cells
Ojogun N, Kahlon A, Ragland SA, Troese MJ, Mastronunzio JE, Walker NJ, VieBrock L, Thomas RJ, Borjesson DL, Fikrig E, Carlyon JA. Anaplasma phagocytophilum Outer Membrane Protein A Interacts with Sialylated Glycoproteins To Promote Infection of Mammalian Host Cells. Infection And Immunity 2012, 80: 3748-3760. PMID: 22907813, PMCID: PMC3486060, DOI: 10.1128/iai.00654-12.Peer-Reviewed Original ResearchConceptsMammalian host cellsHuman granulocytic anaplasmosisHost cellsHL-60 cellsA. phagocytophilum organismsExtracellular domainP-selectin glycoprotein-1Outer Membrane Protein ASialylated glycoproteinsA. phagocytophilum infectionA. phagocytophilum-infected ticksN-terminal regionMembrane protein AObligate intracellular bacteriumAmino acids 19HGA patientsPhagocytophilum infectionInfectionTransmission feedingGlutathione S-transferaseGranulocytic anaplasmosisIntracellular bacteriumGlycoprotein 1Anaplasma phagocytophilumA. phagocytophilum
2008
A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells
Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, Anderson JF, Bushmich SL, Anthony K, Ledizet M, Fikrig E, Koski RA, Kaplan P. A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells. Vaccine 2008, 27: 213-222. PMID: 18996430, PMCID: PMC2651515, DOI: 10.1016/j.vaccine.2008.10.046.Peer-Reviewed Original ResearchConceptsVaccine candidatesClinical adverse effectsProtein vaccine candidateRecombinant vaccine candidateWNV vaccineAntibody titersHumoral immunityProtective efficacySafe vaccineWNV infectionChallenge modelVaccine antigensAnimal modelsViral protectionHigh dosesProtein antigensAdverse effectsImmunogenicitySerum-free cultureAntigenCell linesNaïve foalsVaccineAluminum hydroxideInfectionExtrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae).
Anderson J, Main A, Delroux K, Fikrig E. Extrinsic incubation periods for horizontal and vertical transmission of West Nile virus by Culex pipiens pipiens (Diptera: Culicidae). Journal Of Medical Entomology 2008, 45: 445-51. PMID: 18533438, DOI: 10.1603/0022-2585(2008)45[445:eipfha]2.0.co;2.Peer-Reviewed Original ResearchConceptsWest Nile virusInfection rateVertical transmissionNile virusMinimal infection rateHighest minimum infection rateVertical transmission rateMinimum infection rateWNV 1Extrinsic incubation periodDay 13Day 16Extrinsic incubationMembrane feederCulex pipiens pipiens L.Horizontal transmission ratesInitiation of amplificationFirst bloodmealVirusSurvival of virusesMiceFemalesHamstersHorizontal transmissionWNVExtrinsic Incubation Periods for Horizontal and Vertical Transmission of West Nile Virus by Culex pipiens pipiens (Diptera: Culicidae)
Anderson JF, Main AJ, Delroux K, Fikrig E. Extrinsic Incubation Periods for Horizontal and Vertical Transmission of West Nile Virus by Culex pipiens pipiens (Diptera: Culicidae). Journal Of Medical Entomology 2008, 45: 445-451. DOI: 10.1093/jmedent/45.3.445.Peer-Reviewed Original ResearchConceptsWest Nile virusInfection rateVertical transmissionNile virusMinimal infection rateHighest minimum infection rateVertical transmission rateMinimum infection rateWNV 1Extrinsic incubation periodDay 13Day 16Extrinsic incubationMembrane feederHorizontal transmission ratesCulex pipiens pipiens L.Initiation of amplificationFirst bloodmealVirusSurvival of virusesMiceFemalesHamstersHorizontal transmissionWNV