Progress Towards a Vaccine for Lyme Disease
Telford S, Fikrig E. Progress Towards a Vaccine for Lyme Disease. BioDrugs 1995, 4: 49-60. DOI: 10.1007/bf03259070.Peer-Reviewed Original ResearchLyme diseaseLyme disease vaccineSurface protein AOuter surface protein AProtective immunityPrototype vaccineCareful surveillanceClinical trialsChronic natureDisease vaccineSuch vaccinesMouse modelVaccinated hostAdvanced stageVaccineDiseaseInfectious ticksInfectionAntibodiesProtein AYearsMiceImmunityTrialsEfficacy of Human Lyme Disease Vaccine Formulations in a Mouse Model
Telford SR, Kantor FS, Lobet Y, Barthold SW, Spielman A, Flavell RA, Fikrig E. Efficacy of Human Lyme Disease Vaccine Formulations in a Mouse Model. The Journal Of Infectious Diseases 1995, 171: 1368-1370. PMID: 7751719, DOI: 10.1093/infdis/171.5.1368.Peer-Reviewed Original ResearchConceptsMouse modelC3H/HeJ mouse modelLyme diseaseRecombinant outer surface protein APhase I human trialsPhase II trialSurface protein AUnvaccinated miceII trialVaccinated miceOuter surface protein AVaccine formulationsHuman trialsRecombinant OspAMiceBorrelia burgdorferiDiseaseTrialsMajor siteTrial sitesProtein ATicksImmunizationVaccineInfection