1998
Human Exposure to a Granulocytic Ehrlichia and Other Tick-Borne Agents in Connecticut
Magnarelli L, Ijdo J, Anderson J, Padula S, Flavell R, Fikrig E. Human Exposure to a Granulocytic Ehrlichia and Other Tick-Borne Agents in Connecticut. Journal Of Clinical Microbiology 1998, 36: 2823-2827. PMID: 9738027, PMCID: PMC105071, DOI: 10.1128/jcm.36.10.2823-2827.1998.Peer-Reviewed Original ResearchConceptsHuman monocytic ehrlichiosisWestern blot analysisTick-borne agentsProbable human casesTick-borne infectionsHuman granulocytic ehrlichiosis (HGE) agentBlot analysisSerologic testingMarked leukopeniaSeropositive specimensPositive seraHGE agentLyme borreliosisBabesia microtiHuman casesMonocytic ehrlichiosisEhrlichia equiBorrelia burgdorferiGranulocytic EhrlichiaEhrlichia chaffeensisFrequent detectionHuman exposurePatientsInfectionAntibodiesVaccination against Lyme Disease with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein A with Adjuvant
Steere A, Sikand V, Meurice F, Parenti D, Fikrig E, Schoen R, Nowakowski J, Schmid C, Laukamp S, Buscarino C, Krause D. Vaccination against Lyme Disease with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein A with Adjuvant. New England Journal Of Medicine 1998, 339: 209-215. PMID: 9673298, DOI: 10.1056/nejm199807233390401.Peer-Reviewed Original ResearchConceptsLyme diseaseSerologic testingVaccine efficacyAsymptomatic infectionLipoprotein AInjections of vaccineOuter surface lipoprotein AB. burgdorferi infectionFirst yearPlacebo recipientsPlacebo groupVaccine groupVaccine recipientsStudy entryRandomized trialsSystemic reactionsThird injectionBurgdorferi infectionEffective vaccineSkin lesionsReaction testingVaccineDefinite casesDiseaseInfection
1995
Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection.
Barthold S, Levy S, Fikrig E, Bockenstedt L, Smith A. Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection. Journal Of The American Veterinary Medical Association 1995, 207: 1435-40. PMID: 7493871, DOI: 10.2460/javma.1995.207.11.1435.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialBacterial Outer Membrane ProteinsBacterial ProteinsBacterial VaccinesBiological AssayBlotting, WesternBorrelia burgdorferi GroupDog DiseasesDogsEnzyme-Linked Immunosorbent AssayFemaleImmune SeraImmunoglobulin GImmunoglobulin MLyme DiseaseMaleMiceMice, Inbred C3HVaccinationConceptsSerologic responseAntibiotic treatmentVaccinated dogsRecombinant outer surface proteinPassive protective activityBorrelia burgdorferi infectionMeans of ELISAImmunoblot analysisSeronegative dogsClinical responseSerologic testingClinical criteriaControl dogsAntibody responseMouse protectionB burgdorferiClinical trialsBurgdorferi infectionInfected dogsELISA titersProtective activityOuter surface proteinsUseful antigenDogsBorrelia burgdorferiCoexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera
Magnarelli LA, Dumler JS, Anderson JF, Johnson RC, Fikrig E. Coexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera. Journal Of Clinical Microbiology 1995, 33: 3054-3057. PMID: 8576376, PMCID: PMC228637, DOI: 10.1128/jcm.33.11.3054-3057.1995.Peer-Reviewed Original ResearchConceptsLyme borreliosisTick-borne agentsTick-borne pathogensSerum samplesCoexistence of antibodiesB. microti infectionIndirect fluorescent antibodyMaximal antibody titersConnecticut patientsErythema migransSerologic evidenceSerologic testingClinical pictureAntibody titersTotal immunoglobulinMicroti infectionClinical diagnosisEnd pointBabesia microtiBorrelia burgdorferiEhrlichia chaffeensisBorreliosisFluorescent antibodyAntibodiesE. chaffeensis