2002
Repression of rac2 mRNA Expression by Anaplasma phagocytophila Is Essential to the Inhibition of Superoxide Production and Bacterial Proliferation
Carlyon JA, Chan WT, Galán J, Roos D, Fikrig E. Repression of rac2 mRNA Expression by Anaplasma phagocytophila Is Essential to the Inhibition of Superoxide Production and Bacterial Proliferation. The Journal Of Immunology 2002, 169: 7009-7018. PMID: 12471136, DOI: 10.4049/jimmunol.169.12.7009.Peer-Reviewed Original ResearchConceptsInfected HL-60 cellsHL-60 cellsAnaplasma phagocytophilaMRNA expressionNADPH oxidaseRetinoic acid-differentiated HL-60 cellsBacterial intracellular survivalHuman granulocytic ehrlichiosisNADPH oxidase activityNADPH oxidase activationQuantitative RT-PCRCMV immediate-early promoterInfected neutrophilsEtiologic agentGranulocytic ehrlichiosisRT-PCR analysisA. phagocytophilaIntracellular survivalSuperoxide productionOxidase activationNeutrophilsProtein expressionRT-PCRImmediate early promoterH postinfection
1997
Borrelia burgdorferi P35 and P37 Proteins, Expressed In Vivo, Elicit Protective Immunity
Fikrig E, Barthold S, Sun W, Feng W, Telford S, Flavell R. Borrelia burgdorferi P35 and P37 Proteins, Expressed In Vivo, Elicit Protective Immunity. Immunity 1997, 6: 531-539. PMID: 9175831, DOI: 10.1016/s1074-7613(00)80341-6.Peer-Reviewed Original ResearchConceptsElicit protective immunityB. burgdorferiIgG titersProtective immunityInfected miceImmune responseHost immunityLyme borreliosisRT-PCR analysisMiceVivo-expressed antigensBorrelia burgdorferi genesImmunityP35BurgdorferiP37 proteinVivoNorthern blotAntiserumP37PatientsAntigenELISATitersBorreliosis