2017
Unamplified RNA Sensor for On‐Site Screening of Zika Virus Disease in a Limited Resource Setting
Cheng C, Wu J, Fikrig E, Wang P, Chen J, Eda S, Terry P. Unamplified RNA Sensor for On‐Site Screening of Zika Virus Disease in a Limited Resource Setting. ChemElectroChem 2017, 4: 485-489. DOI: 10.1002/celc.201600831.Peer-Reviewed Original ResearchCopies/μL.Capacitive sensing technologySignal amplificationFalse-positive signalsSite screeningZika virus RNASequence-specific probesSensorsSensing technologyBiosensorLower limitRNA sensorsDetectionField applicationLimited resource settingsVirus RNAConfirmatory laboratory testsΜL.Sensitive meansTechnologyApplications
2015
Nlrp6 regulates intestinal antiviral innate immunity
Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Nlrp6 regulates intestinal antiviral innate immunity. Science 2015, 350: 826-830. PMID: 26494172, PMCID: PMC4927078, DOI: 10.1126/science.aab3145.Peer-Reviewed Original ResearchConceptsI/III interferonIntestinal antiviral innate immunityEncephalomyocarditis virusEnteric virus infectionType I/III interferonsGut microbiota homeostasisAntiviral innate immunityViral RNA sensorsViral loadControl miceVirus infectionGastrointestinal tractMicrobiota homeostasisSimilar mortalityIII interferonsAntibacterial immunityInnate immunityIntestinal tractRNA helicase DHX15MiceViral RNANLRP6Murine norovirus-1RNA sensorsMortality