1995
Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis
Dunne M, al-Ramadi BK, Barthold SW, Flavell RA, Fikrig E. Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis. Infection And Immunity 1995, 63: 1611-1614. PMID: 7890431, PMCID: PMC173199, DOI: 10.1128/iai.63.4.1611-1614.1995.Peer-Reviewed Original ResearchConceptsAnti-OspA antibodyMurine Lyme borreliosisDevelopment of antibodiesMajor outer surface proteinsSalmonella typhimurium strainsOral vaccinationIntradermal challengeMouse modelAttenuated strainOuter surface proteinsHigh titersLyme borreliosisLyme diseaseBorrelia burgdorferiTyphimurium strainsCausative agentDiseaseAntibodiesSurface proteinsSalmonella typhimuriumGavageVaccinationMiceTitersBorreliosis
1991
Protection of Mice from Lyme Borreliosis by Oral Vaccination with Escherichia coli Expressing OspA
Fikrig E, Barthold S, Kantor F, Flavell R. Protection of Mice from Lyme Borreliosis by Oral Vaccination with Escherichia coli Expressing OspA. The Journal Of Infectious Diseases 1991, 164: 1224-1227. PMID: 1955724, DOI: 10.1093/infdis/164.6.1224.Peer-Reviewed Original ResearchConceptsOral vaccinationRecombinant OspARecombinant outer surface protein AProtection of miceSerum IgG antibodiesSurface protein ALast boostOuter surface protein AControl miceChallenge infectionIgG antibodiesIntraperitoneal injectionLive Escherichia coliOral preparationsC3H/Day 10Lyme borreliosisVaccinationMiceInfectionBorrelia burgdorferiOspAAntibodiesProtein AGavage