2011
Innate interleukin-22 confers protection during acute liver infection (114.8)
Zenewicz L, Pedra J, Booth C, Fikrig E, Flavell R. Innate interleukin-22 confers protection during acute liver infection (114.8). The Journal Of Immunology 2011, 186: 114.8-114.8. DOI: 10.4049/jimmunol.186.supp.114.8.Peer-Reviewed Original ResearchLTi-like cellsIL-22Liver infectionLiver immune responseObligate intracellular bacterium Anaplasma phagocytophilumInnate immune cellsLymphoid tissue inducerIL-22 receptorRole of innateIL-22-dependent mannerTissue responseImportant protective roleBacterium Anaplasma phagocytophilumA. phagocytophilum infectionIL-23Liver injuryImmune cellsLymphoid tissueInterleukin-22Immune responseGastrointestinal tractImportant cytokineConfer protectionProtective roleBacterial infections
2006
Gamma Interferon Plays a Crucial Early Antiviral Role in Protection against West Nile Virus Infection
Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma Interferon Plays a Crucial Early Antiviral Role in Protection against West Nile Virus Infection. Journal Of Virology 2006, 80: 5338-5348. PMID: 16699014, PMCID: PMC1472130, DOI: 10.1128/jvi.00274-06.Peer-Reviewed Original ResearchConceptsWest Nile virusGammadelta T cellsIFN-gammaLymphoid tissueT cellsWNV infectionProtective roleSevere central nervous system infectionsCentral nervous system infectionWest Nile virus infectionGreater viral replicationNervous system infectionInfectious West Nile virusLethal WNV infectionPeripheral lymphoid tissuesIFN-gamma productionAlpha/beta interferonBone marrow reconstitution experimentsInnate immune response elementsDominant protective rolePrimary dendritic cellsAverage survival timeImmune response elementsEssential protective roleHigh viremia