2022
CD55 Facilitates Immune Evasion by Borrelia crocidurae, an Agent of Relapsing Fever
Arora G, Lynn GE, Tang X, Rosen CE, Hoornstra D, Sajid A, Hovius JW, Palm NW, Ring AM, Fikrig E. CD55 Facilitates Immune Evasion by Borrelia crocidurae, an Agent of Relapsing Fever. MBio 2022, 13: e01161-22. PMID: 36036625, PMCID: PMC9600505, DOI: 10.1128/mbio.01161-22.Peer-Reviewed Original ResearchConceptsRole of CD55Fever infectionImmune evasionSurface of erythrocytesRosette formationB. crociduraeB. persicaHost factorsBorrelia crociduraeAcute febrile illnessInflammatory cytokine levelsElevated proinflammatory cytokinesExpression of CD55Causative agentErythrocyte rosette formationFacilitates Immune EvasionComplement-mediated lysisHost-pathogen interactionsCytokine levelsFebrile illnessSignificant morbidityProinflammatory cytokinesHigh-throughput screenC5a levelsCD55 expression
2020
TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes
Wang Y, Uraki R, Hwang J, Fikrig E. TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes. Viruses 2020, 12: 519. PMID: 32397176, PMCID: PMC7290343, DOI: 10.3390/v12050519.Peer-Reviewed Original ResearchConceptsZika virusZIKV replicationZIKV NS1 proteinGuillain-Barré syndromeNS1 proteinTRiC/CCT complexPromising therapeutic targetZIKV infectionCongenital microcephalySpecific treatmentTherapeutic targetHost factorsVirusMosquitoesSyndromeVaccineSymptomsInfectionMicrocephalyProteinReplicationImportant role
2019
Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist
Hwang J, Wang Y, Fikrig E. Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist. Antimicrobial Agents And Chemotherapy 2019, 63: 10.1128/aac.01220-19. PMID: 31307983, PMCID: PMC6709483, DOI: 10.1128/aac.01220-19.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsApolipoproteins EATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1Chikungunya virusCholesterolFibroblastsGene Expression RegulationHost-Pathogen InteractionsHumansIndazolesInterferonsLiver X ReceptorsPrimary Cell CultureRNA, Small InterferingSignal TransductionVirus ReplicationConceptsChikungunya virusLiver X receptor agonistMosquito-borne chikungunya virusX receptor agonistLiver X receptorChikungunya Virus ReplicationLXR-623Acute painJoint inflammationReceptor agonistCHIKV replicationPharmacological activationSynthetic agonistsAntiviral stateVirus replicationX receptorLarge epidemicsHost factorsAgonistsPrimary human fibroblastsVirusHuman fibroblastsPainInflammationGeographic areas
2018
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses
Hwang J, Jiang A, Fikrig E. A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses. Antiviral Research 2018, 161: 163-168. PMID: 30521835, PMCID: PMC6345585, DOI: 10.1016/j.antiviral.2018.11.017.Peer-Reviewed Original ResearchConceptsDengue virusSignificant morbiditySafe vaccineSynthetase inhibitionEndemic areasSynthetase inhibitorFlavivirus genusMosquito-bornePotent antagonistHost factorsGroup of pathogensVirusMultiple virusesChikungunyaHematophagous arthropod vectorsAedes sppArthropod vectorsEpidemic pathogensAdditional approachesMorbidityPathogensVaccineAntagonistMortalityHuman population
2003
Borrelia burgdorferi transcriptome in the central nervous system of non-human primates
Narasimhan S, Camaino M, Liang FT, Santiago F, Laskowski M, Philipp MT, Pachner AR, Radolf JD, Fikrig E. Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 15953-15958. PMID: 14671329, PMCID: PMC307674, DOI: 10.1073/pnas.2432412100.Peer-Reviewed Original ResearchConceptsNon-human primate modelB. burgdorferiEffect of dexamethasoneCentral nervous systemHost metabolic pathwaysNon-human primatesNeurological symptomsPaucibacillary natureCNS milieuImmune statusCommon manifestationPrimate modelNervous systemExpression profilesLyme diseaseHost factorsHeart tissueGene expressionB. burgdorferi transcriptomeBorrelia burgdorferiNHPNeuroborreliosisImmunocompetentVivo gene expressionBurgdorferi