2004
CXCR2 Blockade Influences Anaplasma phagocytophilum Propagation but Not Histopathology in the Mouse Model of Human Granulocytic Anaplasmosis
Scorpio DG, Akkoyunlu M, Fikrig E, Dumler JS. CXCR2 Blockade Influences Anaplasma phagocytophilum Propagation but Not Histopathology in the Mouse Model of Human Granulocytic Anaplasmosis. MSphere 2004, 11: 963-968. PMID: 15358660, PMCID: PMC515272, DOI: 10.1128/cdli.11.5.963-968.2004.Peer-Reviewed Original ResearchConceptsHuman granulocytic anaplasmosisControl miceGranulocytic anaplasmosisC3H-scid miceInfected cellsTissue loadsObligate intracellular bacteriumNeutrophil recruitmentNeutrophil secretionAntibody blockadeChemokine inductionHepatic pathologyLiver histopathologyInterleukin-8Tissue injuryMouse modelControl animalsDay 14Intracellular bacteriumMiceInfectionAnaplasma phagocytophilumA. phagocytophilumHistopathologyNeutrophils
1993
Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines.
Telford SR, Fikrig E, Barthold SW, Brunet LR, Spielman A, Flavell RA. Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines. Journal Of Experimental Medicine 1993, 178: 755-758. PMID: 8340764, PMCID: PMC2191140, DOI: 10.1084/jem.178.2.755.Peer-Reviewed Original Research
1992
Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.
Fikrig E, Telford SR, Barthold SW, Kantor FS, Spielman A, Flavell RA. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 5418-5421. PMID: 1608951, PMCID: PMC49303, DOI: 10.1073/pnas.89.12.5418.Peer-Reviewed Original ResearchConceptsRecombinant outer surface protein AVaccine-induced immunityIxodes dammini ticksSurface protein AOuter surface protein ANonimmunized miceImmunized miceSpirochetal infectionTick biteCharacteristic histopathologyImmunized animalsLyme diseaseMiceBorrelia burgdorferiSpirochetesMode of protectionVector ticksOspATicksProtein AHistopathologyInfectionDiseaseImmunity