1997
Borrelia burgdorferi P35 and P37 Proteins, Expressed In Vivo, Elicit Protective Immunity
Fikrig E, Barthold S, Sun W, Feng W, Telford S, Flavell R. Borrelia burgdorferi P35 and P37 Proteins, Expressed In Vivo, Elicit Protective Immunity. Immunity 1997, 6: 531-539. PMID: 9175831, DOI: 10.1016/s1074-7613(00)80341-6.Peer-Reviewed Original ResearchConceptsElicit protective immunityB. burgdorferiIgG titersProtective immunityInfected miceImmune responseHost immunityLyme borreliosisRT-PCR analysisMiceVivo-expressed antigensBorrelia burgdorferi genesImmunityP35BurgdorferiP37 proteinVivoNorthern blotAntiserumP37PatientsAntigenELISATitersBorreliosis
1994
Sera from Patients with Chronic Lyme Disease Protect Mice from Lyme Borreliosis
Fikrig E, Bockenstedt L, Barthold S, Chen M, Tao H, Salaam P, Telford S, Flavell R. Sera from Patients with Chronic Lyme Disease Protect Mice from Lyme Borreliosis. The Journal Of Infectious Diseases 1994, 169: 568-574. PMID: 8158028, DOI: 10.1093/infdis/169.3.568.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupChronic DiseaseFemaleHumansImmunization, PassiveImmunoblottingLipoproteinsLyme DiseaseMiceMice, Inbred C3HPolymerase Chain ReactionPrecipitin TestsConceptsStrong humoral responseLyme diseaseHumoral responseB. burgdorferiLate-stage Lyme diseaseLate Lyme diseaseElicit protective immunityChronic Lyme diseaseStrong antibody reactivityBorrelia burgdorferi challengeSurface protein AMost patientsOuter surface protein AProtective immunityImmune responsePatientsAntibody reactivityHuman antibodiesInfectionLyme borreliosisMiceDiseaseSerumNatural infectionAntibodies
1993
Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice.
Bockenstedt LK, Fikrig E, Barthold SW, Kantor FS, Flavell RA. Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice. The Journal Of Immunology 1993, 151: 900-6. PMID: 8335917, DOI: 10.4049/jimmunol.151.2.900.Peer-Reviewed Original ResearchConceptsA antibodiesOsp AProtective immunityMurine immune responseBorrelia burgdorferiElicit protective immunityGroups of miceDevelopment of antibodiesOuter surface protein A.Vaccine AgsChallenge infectionPassive immunizationActive immunizationImmune responseEtiologic agentIndirect immunofluorescenceLyme diseaseMiceVaccinationA antiseraAntibodiesImmunityConformational epitopesA proteinImmunization