2007
Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion
Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. Journal Of Clinical Investigation 2007, 117: 3059-3066. PMID: 17909632, PMCID: PMC1994625, DOI: 10.1172/jci32218.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorViral neuroinvasionWest Nile virusInvolvement of MIFInhibitory factorProinflammatory cytokine macrophage migration inhibitory factorCytokine macrophage migration inhibitory factorWNV-infected miceBlood-brain barrierLife-threatening encephalitisWild-type miceAcute WNV infectionFlavivirus West Nile virusMIF expressionMIF levelsViral loadWNV encephalitisMIF actionPharmacotherapeutic approachesInflammatory responseWNV infectionCerebrospinal fluidSusceptible individualsInnate immunity
2004
Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease
Fikrig E, Coyle PK, Schutzer SE, Chen M, Deng Z, Flavell RA. Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease. Journal Of Clinical Microbiology 2004, 42: 1243-1246. PMID: 15004083, PMCID: PMC356844, DOI: 10.1128/jcm.42.3.1243-1246.2004.Peer-Reviewed Original ResearchDetection of Human Anti-Flavivirus Antibodies with a West Nile Virus Recombinant Antigen Microsphere Immunoassay
Wong SJ, Demarest VL, Boyle RH, Wang T, Ledizet M, Kar K, Kramer LD, Fikrig E, Koski RA. Detection of Human Anti-Flavivirus Antibodies with a West Nile Virus Recombinant Antigen Microsphere Immunoassay. Journal Of Clinical Microbiology 2004, 42: 65-72. PMID: 14715733, PMCID: PMC321652, DOI: 10.1128/jcm.42.1.65-72.2004.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidWN virusRelated flavivirusesProtein antigensMicrosphere immunoassayAnti-flavivirus antibodiesAnti-human immunoglobulin antibodiesNew York patientsImmunoglobulin G antibodiesPublic health workersWN virus infectionEnzyme-linked immunosorbent assayEnzyme-linked immunosorbentE proteinSt. Louis encephalitisWest Nile virusViral encephalitisIgM antibodiesAnti-IgG antibodiesManagement of outbreaksG antibodiesVirus infectionHealth workersJapanese encephalitisImmunoglobulin antibodies
1992
Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection.
Fikrig E, Barthold SW, Persing DH, Sun X, Kantor FS, Flavell RA. Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. The Journal Of Immunology 1992, 148: 2256-60. PMID: 1545130, DOI: 10.4049/jimmunol.148.7.2256.Peer-Reviewed Original ResearchConceptsSurface protein AOuter surface protein ABorrelia burgdorferi strain N40Vaccination of miceB. burgdorferiImmunized miceVaccination experimentsIntradermal challengeVaccine candidatesCerebrospinal fluidMiceProtein AStrain N40VaccinationStrain 297OspA geneBurgdorferiOspACD16NeuroborreliosisPatientsInfection