2017
Actin Filament Strain Promotes Severing and Cofilin Dissociation
Schramm AC, Hocky GM, Voth GA, Blanchoin L, Martiel JL, De La Cruz EM. Actin Filament Strain Promotes Severing and Cofilin Dissociation. Biophysical Journal 2017, 112: 2624-2633. PMID: 28636918, PMCID: PMC5479148, DOI: 10.1016/j.bpj.2017.05.016.Peer-Reviewed Original ResearchConceptsContinuum mechanics modelStrain energy distributionMechanical propertiesMechanics modelFilament twistingEnhanced spatial resolutionFilament mechanical propertiesElastic energyTorsional rigidityShape deformationSpatial resolutionContinuum modelTorsional flexibilityFilament bendingCofilactin filamentsDynamics simulationsMolecular dynamics simulationsBucklingCofilin-decorated segmentsDeformationBendingBoundariesEnergy distributionLoadFilament model
2015
Mechanical Heterogeneity Favors Fragmentation of Strained Actin Filaments
De La Cruz EM, Martiel JL, Blanchoin L. Mechanical Heterogeneity Favors Fragmentation of Strained Actin Filaments. Biophysical Journal 2015, 108: 2270-2281. PMID: 25954884, PMCID: PMC4423049, DOI: 10.1016/j.bpj.2015.03.058.Peer-Reviewed Original ResearchConceptsMechanical propertiesFilament deformationEnergy densityElastic energyLocal shear forcesDeformation modesFilament strainFilament mechanical propertiesCompliant segmentsMechanical heterogeneityCompressive forceShear forceDeformationFree energy densityElastic free energy densityTwisting rigiditiesShape deformationLocal discontinuitiesSpatial confinementElasticitySevering efficiencyEnergyEnergy gradientConfinementForce
2014
Multi-Platform Compatible Software for Analysis of Polymer Bending Mechanics
Graham JS, McCullough BR, Kang H, Elam WA, Cao W, De La Cruz EM. Multi-Platform Compatible Software for Analysis of Polymer Bending Mechanics. PLOS ONE 2014, 9: e94766. PMID: 24740323, PMCID: PMC3989245, DOI: 10.1371/journal.pone.0094766.Peer-Reviewed Original Research
2011
Cofilin-Linked Changes in Actin Filament Flexibility Promote Severing
McCullough BR, Grintsevich EE, Chen CK, Kang H, Hutchison AL, Henn A, Cao W, Suarez C, Martiel JL, Blanchoin L, Reisler E, De La Cruz EM. Cofilin-Linked Changes in Actin Filament Flexibility Promote Severing. Biophysical Journal 2011, 101: 151-159. PMID: 21723825, PMCID: PMC3127193, DOI: 10.1016/j.bpj.2011.05.049.Peer-Reviewed Original Research
2010
Origin of Twist-Bend Coupling in Actin Filaments
De La Cruz EM, Roland J, McCullough BR, Blanchoin L, Martiel JL. Origin of Twist-Bend Coupling in Actin Filaments. Biophysical Journal 2010, 99: 1852-1860. PMID: 20858430, PMCID: PMC2941021, DOI: 10.1016/j.bpj.2010.07.009.Peer-Reviewed Original Research