Systematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials
Mew E, Monsour A, Saeed L, Santos L, Patel S, Courtney D, Watson P, Szatmari P, Offringa M, Monga S, Butcher N. Systematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials. Journal Of Clinical Epidemiology 2020, 126: 71-79. PMID: 32561367, DOI: 10.1016/j.jclinepi.2020.06.013.Peer-Reviewed Original ResearchConceptsOutcome measurement instrumentsOutcome heterogeneityMajor depressive disorder trialsMajor depressive disorderDepressive symptom severityOutcome termsSingle trialDepression clinical trialPrimary outcomeClinical trialsDepressive disorderDepression trialsSymptom severityLife impactStudy designIdentified outcomesTrial resultsTrialsOutcomesIdentifies heterogeneityDescriptive analysisMeasurement instrumentsTherapySeverityPrimary outcome reporting in adolescent depression clinical trials needs standardization
Monsour A, Mew E, Patel S, Chee-a-tow A, Saeed L, Santos L, Courtney D, Watson P, Monga S, Szatmari P, Offringa M, Butcher N. Primary outcome reporting in adolescent depression clinical trials needs standardization. BMC Medical Research Methodology 2020, 20: 129. PMID: 32450810, PMCID: PMC7247139, DOI: 10.1186/s12874-020-01019-6.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsPrimary outcomeSingle primary outcomeClinical trialsOutcome assessmentDiagnosis of MDDChecklist itemsOutcome assessorsDepression clinical trialClinical guidelinesAdolescent MDDOutcome analysisRCT publicationsMost trialsTrial publicationsOutcome reportingReporting ItemsTreatment interventionsTrial outcomesOutcome informationTrialsHealth careOutcomesSignificant differencesMinimal criteria