2021
GABA-receptive microglia selectively sculpt developing inhibitory circuits
Favuzzi E, Huang S, Saldi G, Binan L, Ibrahim L, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi S, Bonneau R, Datta S, Stevens B, Fishell G. GABA-receptive microglia selectively sculpt developing inhibitory circuits. Cell 2021, 184: 4048-4063.e32. PMID: 34233165, PMCID: PMC9122259, DOI: 10.1016/j.cell.2021.06.018.Peer-Reviewed Original ResearchConceptsInhibitory cortical synapsesBrain wiringResident immune cellsMouse postnatal developmentBehavioral abnormalitiesImmune cellsInhibitory circuitsSynaptic refinementGlial cell typesExcitatory synapsesCortical synapsesPostnatal developmentMicrogliaSynapse typesInhibitory connectionsCell typesBrainRemodeling programSynapsesAbnormalitiesGABA
2019
Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
Favuzzi E, Deogracias R, Marques-Smith A, Maeso P, Jezequel J, Exposito-Alonso D, Balia M, Kroon T, Hinojosa A, F Maraver E, Rico B. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits. Science 2019, 363: 413-417. PMID: 30679375, DOI: 10.1126/science.aau8977.Peer-Reviewed Original ResearchConceptsCortical inhibitory circuitsInhibitory circuitsClasses of GABAergic interneuronsInvestigate transcriptional dynamicsClasses of interneuronsConnectivity patternsAxon initial segmentGABAergic interneuronsMammalian cerebral cortexTranscriptional dynamicsCortical interneuronsPyramidal cellsSynapse specificityPostnatal developmentInterneuron diversityInterneuronsCerebral cortexMolecular mechanismsConnectivity motifsSynaptic moleculesBrain functionMolecular programsNeuronal connectivityInformation processingFunctional networks
2011
The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy
Savino M, Annibali D, Carucci N, Favuzzi E, Cole M, Evan G, Soucek L, Nasi S. The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy. PLOS ONE 2011, 6: e22284. PMID: 21811581, PMCID: PMC3141027, DOI: 10.1371/journal.pone.0022284.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCell SurvivalCells, CulturedDown-RegulationEpigenesis, GeneticFibroblastsHumansIntracellular SpaceMiceMolecular Targeted TherapyNeoplasmsPeptide FragmentsPromoter Regions, GeneticProtein BindingProtein TransportProteinsProto-Oncogene Proteins c-mycRatsRepressor ProteinsSerumTranscription, GeneticTranscriptional ActivationUp-RegulationConceptsMiz-1E-boxTargeting MYCProtein interactionsBinding to E-boxesMyc protein interactionsPromoter E-boxTransactivation of target genesBinding to promotersH3 lysine 9MYC interactomeHLH proteinsRepressed genesCancer therapyLysine 9Gene productsRNA interferenceCancer model in vivoOmomycEpigenetic changesTarget genesGene knockoutDecreased acetylationMYCN-myc