2023
Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing
Ibrahim L, Wamsley B, Alghamdi N, Yusuf N, Sevier E, Hairston A, Sherer M, Jaglin X, Xu Q, Guo L, Jamayran A, Favuzzi E, Yuan Y, Dimidschstein J, Darnell R, Fishell G. Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing. ELife 2023, 12: e86842. PMID: 37347149, PMCID: PMC10287156, DOI: 10.7554/elife.86842.Peer-Reviewed Original ResearchConceptsAlternative splicingSomatostatin interneuronsFamily of RNA-binding proteinsCortical circuit formationRNA-binding proteinsFamily of proteinsActivity-dependent alternative splicingNova familyMouse somatosensory cortexNOVA proteinsBear populationInhibitory cellsAxon formationSplicingSynaptic integrationGene expressionInterneuronsCircuit formationCortical circuitryActivity-dependentSomatosensory cortexSynapse formationBrain developmentSynaptic functionProtein
2022
Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity
Gesuita L, Cavaccini A, Argunsah A, Favuzzi E, Ibrahim L, Stachniak T, De Gennaro M, Utz S, Greter M, Karayannis T. Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity. Cell Reports 2022, 40: 111209. PMID: 35977514, PMCID: PMC9396528, DOI: 10.1016/j.celrep.2022.111209.Peer-Reviewed Original Research