Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing
Ibrahim L, Wamsley B, Alghamdi N, Yusuf N, Sevier E, Hairston A, Sherer M, Jaglin X, Xu Q, Guo L, Jamayran A, Favuzzi E, Yuan Y, Dimidschstein J, Darnell R, Fishell G. Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing. ELife 2023, 12: e86842. PMID: 37347149, PMCID: PMC10287156, DOI: 10.7554/elife.86842.Peer-Reviewed Original ResearchConceptsAlternative splicingSomatostatin interneuronsFamily of RNA-binding proteinsCortical circuit formationRNA-binding proteinsFamily of proteinsActivity-dependent alternative splicingNova familyMouse somatosensory cortexNOVA proteinsBear populationInhibitory cellsAxon formationSplicingSynaptic integrationGene expressionInterneuronsCircuit formationCortical circuitryActivity-dependentSomatosensory cortexSynapse formationBrain developmentSynaptic functionProteinThe brain's polymath: Emerging roles of microglia throughout brain development
Wong F, Favuzzi E. The brain's polymath: Emerging roles of microglia throughout brain development. Current Opinion In Neurobiology 2023, 79: 102700. PMID: 36848726, DOI: 10.1016/j.conb.2023.102700.Peer-Reviewed Original ResearchConceptsPotential contribution of microgliaResident brain immune cellsInfluence neuronal connectivityBrain immune cellsDevelopment of functional networksContribution of microgliaNeuronal circuit developmentElements of neural circuitsImmune cellsNeuronal activityExtracellular matrixSynapse pruningNeuron numberPrune synapsesMicrogliaBrain developmentNeuronal connectivityNeural circuitsBrain wiringCircuit developmentFunctional networksBrainIntegrative viewCircuit wiringIncreased understanding