2022
A genetically informed Registered Report on adverse childhood experiences and mental health
Baldwin J, Sallis H, Schoeler T, Taylor M, Kwong A, Tielbeek J, Barkhuizen W, Warrier V, Howe L, Danese A, McCrory E, Rijsdijk F, Larsson H, Lundström S, Karlsson R, Lichtenstein P, Munafò M, Pingault J. A genetically informed Registered Report on adverse childhood experiences and mental health. Nature Human Behaviour 2022, 7: 269-290. PMID: 36482079, PMCID: PMC7614239, DOI: 10.1038/s41562-022-01482-9.Peer-Reviewed Original ResearchConceptsMental health problemsAdverse childhood experiencesHealth problemsElevated riskMental healthGenetic confoundingChildhood experiencesPsychiatric vulnerabilityGenetic riskHigher polygenic scoresConfoundingChildrenPrevious associationsRiskGene-environment correlationSmall increaseAssociationHealthReportPolygenic scores
2021
Child Maltreatment, Peer Victimization, and Mental Health: Neurocognitive Perspectives on the Cycle of Victimization
Goemans A, Viding E, McCrory E. Child Maltreatment, Peer Victimization, and Mental Health: Neurocognitive Perspectives on the Cycle of Victimization. Trauma Violence & Abuse 2021, 24: 530-548. PMID: 34355601, PMCID: PMC10009486, DOI: 10.1177/15248380211036393.Peer-Reviewed Original ResearchConceptsMental healthMental health careMental health outcomesAdverse childhood experiencesMental health vulnerabilitiesSystematic scoping reviewInpatient populationChild maltreatmentHealth outcomesGoogle ScholarHealth careNeurocognitive functioningPutative mechanismsRisk of revictimizationScoping ReviewHealth vulnerabilityChildrenNeurocognitive findingsPreventative modelAdditive effectChildhood experiencesRiskPeer victimizationHealthMaltreatment
2020
The case for a preventative approach to mental health: Childhood maltreatment, neuroimaging, and the theory of latent vulnerability
McCrory E. The case for a preventative approach to mental health: Childhood maltreatment, neuroimaging, and the theory of latent vulnerability. 2020, 175-189. DOI: 10.1093/med/9780198789697.003.0011.Peer-Reviewed Original ResearchPsychiatric disordersChildhood maltreatmentFuture psychiatric disordersMagnetic resonance imaging researchClinical studiesLatent vulnerabilityClinical approachFunctional magnetic resonance imaging (fMRI) researchEarly adverse environmentsAltered functioningMental healthDisordersPreventative approachMaltreatmentImaging research
2019
A review of childhood maltreatment, latent vulnerability and the brain: implications for clinical practice and prevention
Gerin M, Hanson E, Viding E, McCrory E. A review of childhood maltreatment, latent vulnerability and the brain: implications for clinical practice and prevention. Adoption & Fostering 2019, 43: 310-328. DOI: 10.1177/0308575919865356.Peer-Reviewed Original ResearchMental health problemsLatent vulnerabilityNeurocognitive alterationsChildhood maltreatmentFuture mental health problemsEarly adverse environmentsCommon mental health problemsEmotion regulationThreat processingExecutive controlNeurocognitive systemsHealth problemsPoor mental healthReward processingMaltreated childrenFunctional neuroimagingFuture psychopathologyChild maltreatmentMental healthMaltreatmentLong-term outcomesSuch experiencesFunctioningClinical implicationsChildrenHeightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment
Gerin M, Viding E, Pingault J, Puetz V, Knodt A, Radtke S, Brigidi B, Swartz J, Hariri A, McCrory E. Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment. Journal Of Child Psychology And Psychiatry 2019, 60: 752-761. PMID: 30933355, PMCID: PMC6594878, DOI: 10.1111/jcpp.13041.Peer-Reviewed Original ResearchConceptsMajor stressful life eventsStressful life eventsAmygdala reactivityChildhood maltreatmentLife eventsInternalizing disordersBaseline internalizing symptomsInternalizing symptomsHistory of maltreatmentThreat-related amygdala reactivityDevelopmental insultsPsychiatric riskPropensity scoreSymptomsFuture internalizing symptomsStress exposureMental healthYoung adultsSeverity 1Socioeconomic statusFuture psychopathologyPotent predictorSuch alterationsNonmaltreated peersMaltreatment status
2018
A transdiagnostic neuroanatomical signature of psychiatric illness
Gong Q, Scarpazza C, Dai J, He M, Xu X, Shi Y, Zhou B, Vieira S, McCrory E, Ai Y, Yang C, Zhang F, Lui S, Mechelli A. A transdiagnostic neuroanatomical signature of psychiatric illness. Neuropsychopharmacology 2018, 44: 869-875. PMID: 30127342, PMCID: PMC6461829, DOI: 10.1038/s41386-018-0175-9.Peer-Reviewed Original ResearchConceptsHealthy controlsPsychiatric illnessFamilial vulnerabilityUnaffected first-degree relativesFirst-degree relativesSeverity of symptomsGray matter volumeGreater gray matter volumePost-traumatic stress disorderStructural magnetic resonanceDifferent diagnostic categoriesFamily-wise error correctionPutamen enlargementObsessive-compulsive disorderPsychiatric diagnosisMatter volumePutamen volumePsychiatric groupsGeneral psychopathologyNeuroanatomical signatureUnaffected relativesStress disorderTransdiagnostic alterationsDiagnostic categoriesMental health
2017
Concurrent and Longitudinal Contribution of Exposure to Bullying in Childhood to Mental Health: The Role of Vulnerability and Resilience
Singham T, Viding E, Schoeler T, Arseneault L, Ronald A, Cecil C, McCrory E, Rijsdijk F, Pingault J. Concurrent and Longitudinal Contribution of Exposure to Bullying in Childhood to Mental Health: The Role of Vulnerability and Resilience. JAMA Psychiatry 2017, 74: 1112-1119. PMID: 28979965, PMCID: PMC5710218, DOI: 10.1001/jamapsychiatry.2017.2678.Peer-Reviewed Original ResearchConceptsYears of ageMental healthTwin differences designDissipation of effectsPopulation-based cohortContribution of exposureConduct problemsMental health assessmentPoor mental healthLongitudinal contributionMean ageSecondary interventionsTwins Early Development StudyMAIN OUTCOMEMultidimensional Peer Victimization ScalePeer Victimization ScaleChildhood exposureLast assessmentEarly Development StudyConcurrent anxietyPsychotic-like experiencesRole of vulnerabilityChildhoodAgeCognitive disorganization
2016
Disentangling the mental health impact of childhood abuse and neglect
Cecil C, Viding E, Fearon P, Glaser D, McCrory E. Disentangling the mental health impact of childhood abuse and neglect. Child Abuse & Neglect 2016, 63: 106-119. PMID: 27914236, DOI: 10.1016/j.chiabu.2016.11.024.Peer-Reviewed Original ResearchConceptsMental healthMaltreatment typesMain independent predictorsMental health impactMental health outcomesCommunity violence exposureIndependent predictorsTrauma-related symptomsOutcome measuresPsychiatric symptomsHigh-risk youthHealth outcomesPsychiatric symptomatologySocio-demographic variablesSymptom severityNeighbourhood deprivationViolence exposureChildhood abuseHealth impactsCommunity sampleSymptomsIndividual responsesSpecific effectsCurrent studyEmotional abuse
2015
Child maltreatment
Danese A, McCrory E. Child maltreatment. 2015, 364-375. DOI: 10.1002/9781118381953.ch29.Peer-Reviewed Original ResearchPhysical health impairmentPrompt recognitionPrimary preventionInflammatory responseEffective treatmentChild maltreatmentMarked distressChronic stressBrain structuresHealth impairmentMental healthLevel of interventionEncouraging findingsImpairmentMaltreatmentSexual abuseAbuse experiencesSequelaeAcademic functioningEmotional maltreatmentPrevention
2014
Double disadvantage: the influence of childhood maltreatment and community violence exposure on adolescent mental health
Cecil C, Viding E, Barker E, Guiney J, McCrory E. Double disadvantage: the influence of childhood maltreatment and community violence exposure on adolescent mental health. Journal Of Child Psychology And Psychiatry 2014, 55: 839-848. PMID: 24611776, DOI: 10.1111/jcpp.12213.Peer-Reviewed Original ResearchConceptsCommunity violence exposureTrauma-related symptomsRisk factorsChildhood maltreatmentCommunity violenceMental healthChildhood maltreatment exposureViolence exposureForms of adversityMental health domainsEnvironmental risk factorsMental health functioningKey risk factorsMental health outcomesAdolescent mental healthClinical symptomsHigh-risk adolescentsIndependent associationHealth functioningHealth outcomesSymptomsMaltreatment exposureYoung adultsHealth domainsLatent profile analysis
2013
Antisocial and Callous Behaviour in Children
Viding E, Seara-Cardoso A, McCrory E. Antisocial and Callous Behaviour in Children. Current Topics In Behavioral Neurosciences 2013, 17: 395-419. PMID: 24357438, DOI: 10.1007/7854_2013_266.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsAntisocial behaviorBrain imaging researchDevelopmental psychopathology researchProfiles of vulnerabilitySubstantial public health costsNeuroscience findingsPsychopathology researchCallous behaviorDevelopmental vulnerabilityMental healthImaging researchCurrent evidence baseFuture researchPublic health costsChildrenCommon reasonEvidence baseHeterogeneous groupHealth costsDistinct subgroupsTraitsInterventionResearchBehavior