2013
Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism
Willsey AJ, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, Reilly SK, Lin L, Fertuzinhos S, Miller JA, Murtha MT, Bichsel C, Niu W, Cotney J, Ercan-Sencicek AG, Gockley J, Gupta AR, Han W, He X, Hoffman EJ, Klei L, Lei J, Liu W, Liu L, Lu C, Xu X, Zhu Y, Mane SM, Lein ES, Wei L, Noonan JP, Roeder K, Devlin B, Sestan N, State MW. Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism. Cell 2013, 155: 997-1007. PMID: 24267886, PMCID: PMC3995413, DOI: 10.1016/j.cell.2013.10.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainChild Development Disorders, PervasiveExomeFemaleFetusGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiceMutationNeuronsPrefrontal CortexSequence Analysis, DNAConceptsCoexpression networkASD genesComplex developmental syndromeGenome-wide sequencingCortical projection neuronsHigh-confidence ASD genesExpression data setsPleiotropic genesSpecific genesDevelopmental processesDevelopmental syndromesSequencing studiesGenesProjection neuronsCell typesBrain regionsType mutationsCommon phenotypeASD pathophysiologyPathogenesis of autismAutism spectrum disorderMutationsHuman brain regionsUnknown etiologyRecent studies
2010
Progress in Cytogenetics: Implications for Child Psychopathology
Hoffman EJ, State MW. Progress in Cytogenetics: Implications for Child Psychopathology. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 736-751. PMID: 20643309, DOI: 10.1016/j.jaac.2010.03.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityChildChild Development Disorders, PervasiveCytogeneticsForecastingGenetic VariationHumansMental DisordersPsychopathologySchizophreniaSchizophrenic PsychologyTourette SyndromeConceptsChromosomal structureHuman genetic variationSequence of DNAChromosomal variationMicroarray-based detectionGenetic variationGenetic basisMolecular cytogeneticsGenetic underpinningsMicroarray technologySynapse functionKey discoveriesStructural variationsRecent findingsUnaffected individualsChromosomal studiesCytogenetic investigationsDevelopmental neuropsychiatric disordersCytogeneticsLight microscopyChromosomesGeneticsDNADramatic increasePhenotype