Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice
Weiss L, Bernstein S, Jones R, Amunugama R, Krizman D, JeBailey L, Hazan O, Yachtin J, Shiner R, Reibstein I, Triche E, Slavin S, Or R, Barnea E. Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice. Endocrine 2011, 40: 41. PMID: 21424847, DOI: 10.1007/s12020-011-9438-5.Peer-Reviewed Original ResearchConceptsIntraperitoneal glucose tolerance testInsulin stainingPreImplantation FactorPancreatic functionPreventive effectNormal intraperitoneal glucose tolerance testsIslet architectureType 1 diabetes mellitusPancreatic islet insulinOnset of diabetesGlucose tolerance testExocrine pancreatic functionDiabetic murine modelInsulin receptor expressionPathway analysisSPIF effectNOD miceDiabetes mellitusSignal pathway analysisNeutrophil invasionTh1 cytokinesDiabetes developmentMellitus developmentContinuous administrationMaternal immunity