Excretion of urine extracellular vesicles bearing markers of activated immune cells and calcium/phosphorus physiology differ between calcium kidney stone formers and non-stone formers
Zhang J, Kumar S, Jayachandran M, Herrera Hernandez L, Wang S, Wilson E, Lieske J. Excretion of urine extracellular vesicles bearing markers of activated immune cells and calcium/phosphorus physiology differ between calcium kidney stone formers and non-stone formers. BMC Nephrology 2021, 22: 204. PMID: 34074247, PMCID: PMC8170929, DOI: 10.1186/s12882-021-02417-8.Peer-Reviewed Original ResearchConceptsNon-stone formersCalcium oxalate stone formersUrinary extracellular vesiclesStone formersExtracellular vesiclesKidney stone formersUrinary stone diseaseStone removal surgeryDifferent nephron segmentsImmune cellsStone diseasePathogenic mechanismsRemoval surgeryNephron segmentsUrine samplesPhosphorus physiologyProtein markersPrevious studiesSurgeryPhysiologyExcretionDiseaseHuman kidney stones: a natural record of universal biomineralization
Sivaguru M, Saw J, Wilson E, Lieske J, Krambeck A, Williams J, Romero M, Fouke K, Curtis M, Kear-Scott J, Chia N, Fouke B. Human kidney stones: a natural record of universal biomineralization. Nature Reviews Urology 2021, 18: 404-432. PMID: 34031587, DOI: 10.1038/s41585-021-00469-x.Peer-Reviewed Original ResearchConceptsHot spring depositsCalcium-rich mineralsFields of geologyFundamental natural processesBillions of yearsDisequilibrium precipitationParagenetic sequenceConcentric zoningDeep subsurfaceNatural recordsSector zoneRoman aqueductCoral reefsNatural processesBroad length scalesCrystal aggregatesIndividual stonesHydroxyapatite spherulesThermodynamic energeticsOrders of magnitudeNew transdisciplinary approachDissolutionTotal volumeRecrystallizationStratigraphyIn Vivo Entombment of Bacteria and Fungi during Calcium Oxalate, Brushite, and Struvite Urolithiasis.
Saw J, Sivaguru M, Wilson E, Dong Y, Sanford R, Fields C, Cregger M, Merkel A, Bruce W, Weber J, Lieske J, Krambeck A, Rivera M, Large T, Lange D, Bhattacharjee A, Romero M, Chia N, Fouke B. In Vivo Entombment of Bacteria and Fungi during Calcium Oxalate, Brushite, and Struvite Urolithiasis. Kidney360 2021, 2: 298-311. PMID: 35373025, PMCID: PMC8740987, DOI: 10.34067/kid.0006942020.Peer-Reviewed Original Research