2024
Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering
Delgado-García L, Ojalvo-Sanz A, Nakamura T, Martín-López E, Porcionatto M, Lopez-Mascaraque L. Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering. Biological Research 2024, 57: 54. PMID: 39143594, PMCID: PMC11323641, DOI: 10.1186/s40659-024-00532-y.Peer-Reviewed Original Research
2023
Microglia Maintain Homeostatic Conditions in the Developing Rostral Migratory Stream
Meller S, Hernandez L, Martin-Lopez E, Kloos Z, Liberia T, Greer C. Microglia Maintain Homeostatic Conditions in the Developing Rostral Migratory Stream. ENeuro 2023, 10: eneuro.0197-22.2023. PMID: 36697258, PMCID: PMC9910579, DOI: 10.1523/eneuro.0197-22.2023.Peer-Reviewed Original Researchα-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2019
Embryonic and postnatal development of mouse olfactory tubercle
Martin-Lopez E, Xu C, Liberia T, Meller SJ, Greer CA. Embryonic and postnatal development of mouse olfactory tubercle. Molecular And Cellular Neuroscience 2019, 98: 82-96. PMID: 31200100, DOI: 10.1016/j.mcn.2019.06.002.Peer-Reviewed Original ResearchConceptsOlfactory tubercleVentral striatumOlfactory bulb projection neuronsPrimary afferent inputTyrosine hydroxylase expressionLateral ganglionic eminenceDopamine reward systemCNPase stainingVentral medial regionDopaminergic innervationProjection neuronsStriatal neuronsVentral tegmentumAfferent inputDopaminergic inputLaminar distributionMedial gradientHydroxylase expressionNucleus accumbensGanglionic eminencePostnatal developmentE11-E15OT cellsVentral lateral ganglionic eminencePostnatal stages
2018
Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies
Martin-Lopez E, Meller SJ, Greer CA. Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies. Brain Structure And Function 2018, 223: 4067-4085. PMID: 30141078, PMCID: PMC6252112, DOI: 10.1007/s00429-018-1741-y.Peer-Reviewed Original ResearchConceptsAnterior commissurePostnatal developmentPostnatal day 22Inter-hemispheric connectionsChondroitin sulfate proteoglycanPiriform cortexContralateral innervationGlial cellsOlfactory areasBed nucleusInterhemispheric connectionsStria terminalisDay 22Axonal tractsAxon growthNew subtypeAxon outgrowthCalretininCommissureSulfate proteoglycanAxonsPhenotypeInnervationIpsiImmunohistochemistry
2017
The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage
Martin-Lopez E, Ishiguro K, Greer CA. The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage. Cerebral Cortex 2017, 29: 1-16. PMID: 29136113, PMCID: PMC7199997, DOI: 10.1093/cercor/bhx291.Peer-Reviewed Original ResearchConceptsLaminar specificityLaminar organizationNeurogenesis/gliogenesisPrimary afferent inputNeurogenic patternPiriform cortexAfferent inputNeurogenic gradientOlfactory bulbLayers IIGlial organizationNeuronal migrationPC progenitorsLaminar developmentCortexFunctional organizationClonal analysisCell lineagesLikely roleEarly developmentPaleocortexAnteriorNeurogenesisSpecificityGliogenesis
2013
Clonal Astrocytic Response to Cortical Injury
Martín-López E, García-Marques J, Núñez-Llaves R, López-Mascaraque L. Clonal Astrocytic Response to Cortical Injury. PLOS ONE 2013, 8: e74039. PMID: 24040158, PMCID: PMC3769363, DOI: 10.1371/journal.pone.0074039.Peer-Reviewed Original ResearchConceptsDays post injuryHigher proliferative responsesCentral nervous systemCortical injuryStrong morphological alterationsAstrocytic responsePost injuryBrain injuryGlial functionGlial cellsProliferative responseImmunohistochemical analysisNervous systemAstrocyte heterogeneitySame cloneInjuryMechanical injuryAstrocytesMorphological alterationsClonal responseHeterogeneous populationDistinct clonesCell lineagesMorphological changesMultifaceted role
2011
Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages
Martín-López E, Blanchart A, De Carlos JA, López-Mascaraque L. Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages. PLOS ONE 2011, 6: e26673. PMID: 22046330, PMCID: PMC3201967, DOI: 10.1371/journal.pone.0026673.Peer-Reviewed Original ResearchConceptsWild-type miceOlfactory bulb layersEarly postnatal stagesDab1 expressionEarly brain developmentProjection neuronsReeler miceOlfactory bulbType miceBrain developmentPostnatal stagesProtein expressionBulb layersExpression levelsDab1MiceNeuronsReelin effectsPresent studyReelerRELNCritical rolePossible regulationApparent differencesAdaptor protein
2010
Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb)
Blanchart A, Martín‐López E, De Carlos JA, López‐Mascaraque L. Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb). Glia 2010, 59: 278-292. PMID: 21125652, DOI: 10.1002/glia.21100.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBromodeoxyuridineCell MovementCell ProliferationCells, CulturedEmbryo, MammalianFemaleGene Expression Regulation, DevelopmentalGene Transfer TechniquesGreen Fluorescent ProteinsMiceNerve Tissue ProteinsNeurogliaNeuronsOlfactory BulbOlfactory PathwaysPregnancyProsencephalonConceptsMigratory massCell populationsOlfactory axonsDifferent neural cell populationsOlfactory placodeOlfactory Ensheathing CellsCentral nervous systemLater postnatal stagesEmbryonic day 11Glial markersRetroviral injectionCNS neuronsNeural cell populationsGlomerular layerOlfactory nerveOlfactory bulbPeripheral contributionsNervous systemOlfactory epitheliumDifferent cell populationsDay 11Telencephalic vesiclePostnatal stagesInfected cellsOlfactory system