2017
Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp.
Schwalm ND, Groisman EA. Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp. Trends In Microbiology 2017, 25: 1005-1015. PMID: 28733133, DOI: 10.1016/j.tim.2017.06.009.Peer-Reviewed Original ResearchPrioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron
Schwalm ND, Townsend GE, Groisman EA. Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron. Molecular Microbiology 2017, 104: 32-45. PMID: 28009067, DOI: 10.1111/mmi.13609.Peer-Reviewed Original ResearchConceptsBacteroides thetaiotaomicronGut symbiotic bacteriumSites of phosphorylationB. thetaiotaomicronDiauxic growthTwo-component systemResponse regulatorSensor kinaseMyriad of hostPolysaccharide utilizationUnaltered growthSymbiotic bacteriumMammalian gutSingle polypeptideMultiple polysaccharidesSingle polysaccharidePhosphorylationSpecific signalsPresence of glucoseThetaiotaomicronTranscriptionGenesBacteriumArabinanPolysaccharides
2016
Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron
Schwalm ND, Townsend GE, Groisman EA. Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron. MBio 2016, 7: 10.1128/mbio.01342-16. PMID: 27729509, PMCID: PMC5061871, DOI: 10.1128/mbio.01342-16.Peer-Reviewed Original ResearchConceptsMammalian gut microbiotaPolysaccharide utilization genesUtilization genesHost dietGut symbiont Bacteroides thetaiotaomicronComplex polysaccharidesBacteroides thetaiotaomicronPleiotropic transcriptional regulatorDomains of lifeSubset of organismsRegulatory paradigmCritical nutrient sourceTranscriptional activatorTranscriptional regulatorsTranscriptional repressorCentral metabolismGenomic analysisMammalian gutMammalian hostsRegulatory architectureGut BacteroidesPolymeric fructanGut microbiotaGut bacteriumPolysaccharide breakdown
2015
Species-Specific Dynamic Responses of Gut Bacteria to a Mammalian Glycan
Raghavan V, Groisman EA. Species-Specific Dynamic Responses of Gut Bacteria to a Mammalian Glycan. Journal Of Bacteriology 2015, 197: 1538-1548. PMID: 25691527, PMCID: PMC4403648, DOI: 10.1128/jb.00010-15.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacteroidesChondroitin SulfatesGastrointestinal TractGene Expression ProfilingGene Expression Regulation, BacterialMammalsConceptsUtilization genesRelated speciesBacterial speciesBacteroides speciesPolysaccharide utilization genesCase of genesGut bacteriaGut bacterial speciesOrthologous genesCommunity compositionExpression dynamicsMammalian glycansSole carbon sourceRelated microbesBacterial communitiesMicrobial speciesMammalian intestineSame geneStable coexistenceGut microbial compositionDifferential regulationExpression behaviorGenesMicrobial compositionSustained activation
2014
Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium
Raghavan V, Lowe EC, Townsend GE, Bolam DN, Groisman EA. Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium. Molecular Microbiology 2014, 93: 1010-1025. PMID: 25041429, DOI: 10.1111/mmi.12714.Peer-Reviewed Original ResearchMeSH KeywordsBacterial ProteinsBacteroidesChondroitin SulfatesGastrointestinal TractHumansTranscription, GeneticConceptsUtilization genesRate-determining enzymeGut symbiont Bacteroides thetaiotaomicronB. thetaiotaomicronExcess chondroitin sulfateCatabolic genesChondroitin sulfateNutrient availabilityConstitutive expressionBacteroides thetaiotaomicronGenesGut environmentCatabolic rateTranscriptionTransient increaseThetaiotaomicronAnalogous mechanismEnzymeRegulatorExposureTranscripts