2009
Control of Salmonella pathogenicity island-2 gene expression
Fass E, Groisman EA. Control of Salmonella pathogenicity island-2 gene expression. Current Opinion In Microbiology 2009, 12: 199-204. PMID: 19264535, PMCID: PMC2805070, DOI: 10.1016/j.mib.2009.01.004.Peer-Reviewed Original ResearchConceptsSPI-2 genesTwo-component systems PhoP/PhoQOmpR/EnvZType III secretion systemDifferent pathogenicity islandsSalmonella pathogenicity island 2PhoP/PhoQPathogenicity island 2H-NSEffector proteinsProtein IHFSecretion systemGene expressionRobust silencingIsland 2Pathogenicity islandHost cellsGenesExpressionEnvZSlyASsrBPhoQTranscriptionSilencing
2001
Salmonella enterica Serovar Typhimurium Response Involved in Attenuation of Pathogen Intracellular Proliferation
Cano D, Martı́nez-Moya M, Pucciarelli M, Groisman E, Casadesús J, Portillo F. Salmonella enterica Serovar Typhimurium Response Involved in Attenuation of Pathogen Intracellular Proliferation. Infection And Immunity 2001, 69: 6463-6474. PMID: 11553591, PMCID: PMC98782, DOI: 10.1128/iai.69.10.6463-6474.2001.Peer-Reviewed Original ResearchConceptsIntracellular growth rateIntracellular bacterial viabilityIntracellular proliferation rateNormal rat kidney fibroblastsBacterial overgrowthNonphagocytic host cellsRat kidney fibroblastsNormal fibroblast cellsIntracellular bacterial proliferationMacrophage cellsIntracellular proliferationIntracellular bacteriaKidney fibroblastsVirulence genesFunction mutationsProliferation rateHost cellsBacterial proliferationSerovar TyphimuriumPhoP-PhoQ systemS. entericaProliferationCellsSalmonella enterica
2000
The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri
Moss J, Fisher P, Vick B, Groisman E, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular Microbiology 2000, 2: 443-452. PMID: 11207599, DOI: 10.1046/j.1462-5822.2000.00065.x.Peer-Reviewed Original ResearchConceptsWild-type strainPhoP mutantPhoP/PhoQ systemTwo-component regulatory systemRegulatory protein PhoPHost cell phagosomesPhoP/PhoQKey virulence genesMutant bacteriaEnteric bacteriumPathogen escapeCell phagosomesHost cellsMutantsWild-type ShigellaPolymorphonuclear leucocytesRegulatory systemVirulence genesAntimicrobial moleculesAntimicrobial peptidesPhoPExtreme acidInflammatory responseEpithelial cellsPhagosomesMolecular mechanisms of Salmonella pathogenesis
Groisman EA, Mouslim C. Molecular mechanisms of Salmonella pathogenesis. Current Opinion In Infectious Diseases 2000, 13: 519-522. PMID: 11964823, DOI: 10.1097/00001432-200010000-00014.Peer-Reviewed Original Research
1999
Pathogenicity Islands and the Evolution of Salmonella Virulence
Groisman E, Blanc‐Potard A, Uchiya K. Pathogenicity Islands and the Evolution of Salmonella Virulence. 1999, 127-150. DOI: 10.1128/9781555818173.ch7.Peer-Reviewed Original ResearchSPI-1 genesPathogenicity islandDNA segmentsSPI-1Evolution of SalmonellaCultured epithelial cellsSalmonella-specific sequenceTRNA genesExport apparatusTranscriptional unitsLarge operonNonhost environmentsSecretion systemBacterial entryHousekeeping genesSalmonella virulenceHost rangeSPI-2Secretory systemHost cellsAspects of infectionNonphagocytic cellsGenesMacrophage apoptosisOperon
1998
The ins and outs of virulence gene expression: Mg2+ as a regulatory signal
Groisman E. The ins and outs of virulence gene expression: Mg2+ as a regulatory signal. BioEssays 1998, 20: 96-101. PMID: 9504051, DOI: 10.1002/(sici)1521-1878(199801)20:1<96::aid-bies13>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsSignal transduction systemTransduction systemCellular locationPhoP/PhoQ systemPathogen Salmonella enterica serovar TyphimuriumIntracellular pathogen Salmonella enterica serovar TyphimuriumTranscription of genesPhoP/PhoQVirulence gene expressionFacultative intracellular pathogen Salmonella enterica serovar TyphimuriumSalmonella enterica serovar TyphimuriumDifferent cell typesRegulatory hierarchyEnterica serovar TyphimuriumRegulatory signalsExtracellular environmentGene expressionHost cellsHost cuesCell typesMultiple environmentsSerovar TyphimuriumPrecise tissuePhoQTranscription
1997
A green light for virulence gene expression
Groisman E. A green light for virulence gene expression. Nature Medicine 1997, 3: 1190-1191. PMID: 9359685, DOI: 10.1038/nm1197-1190.Peer-Reviewed Original Research
1996
Identification of a pathogenicity island required for Salmonella survival in host cells.
Ochman H, Soncini FC, Solomon F, Groisman EA. Identification of a pathogenicity island required for Salmonella survival in host cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7800-7804. PMID: 8755556, PMCID: PMC38828, DOI: 10.1073/pnas.93.15.7800.Peer-Reviewed Original ResearchConceptsPathogenicity islandType III secretion systemSalmonella typhimurium chromosomeWild-type levelsEpithelial cell invasionWild-type strainSPI genesSecretion systemPutative regulatorHost cellsSecretory apparatusCell invasionSecreted proteaseVirulence determinantsSpi(-) mutantsGenesProteinProteaseSalmonella survivalEnteric pathogensMutantsChromosomesIslandsCulture supernatantsForms of flagellin
1995
Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica.
Li J, Ochman H, Groisman EA, Boyd EF, Solomon F, Nelson K, Selander RK. Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 7252-7256. PMID: 7638176, PMCID: PMC41317, DOI: 10.1073/pnas.92.16.7252.Peer-Reviewed Original ResearchConceptsEvolutionary ratesInvasion genesInvasion proteinsCellular locationSequence identityProtein export systemNonphagocytic host cellsWarm-blooded vertebratesEnteric pathogens ShigellaSalmonella entericaS. entericaEvolutionary diversificationNiche expansionExport systemExtracellular environmentHost cellsSPA complexGenesEnteric bacteriaProteinFlagellar phaseKey eventsSubspeciesHomologuesSpa geneThe evolution off invasion by enteric bacteria
Ochman H, Groisman EA. The evolution off invasion by enteric bacteria. Canadian Journal Of Microbiology 1995, 41: 555-561. PMID: 7641138, DOI: 10.1139/m95-074.Peer-Reviewed Original ResearchConceptsPhylogenetic distributionGenomic locationPlant pathogensDivergent pathogensSecretory pathwayVirulence proteinsGene complexHost rangeHost cellsSimilar machineryEnteric bacteriaPathogensProteinDisease pathologyEnteric pathogensMachineryBacteriaPathwayShigella sppSppAnalogous structuresSequenceInvasionCellsComplexes