Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation
Duy PQ, David WB, Kahle KT. Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation. Frontiers In Cellular Neuroscience 2019, 13: 515. PMID: 31803025, PMCID: PMC6873151, DOI: 10.3389/fncel.2019.00515.Peer-Reviewed Original ResearchHuman epilepsySignificant drug-related adverse effectsDrug-related adverse effectsMedication-refractory epilepsyDevelopment of epilepsyCommon neurological disorderPotential therapeutic strategyKCC2 dysfunctionNeuronal hyperexcitabilityGABA inhibitionGABAergic inhibitionSeizure disorderUnprovoked seizuresImpaired balanceKCC2 activityNeuronal excitabilityNeuronal excitationTherapeutic strategiesTransporter modulationEpileptic seizuresEpilepsyNeurological disordersChloride homeostasisSatisfactory treatmentAdverse effects