2023
Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort
Westwater M, Mallard T, Warrier V, Bethlehem R, Scheinost D, Grillon C, Fletcher P, Seidlitz J, Ernst M. Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort. Nature Mental Health 2023, 1: 573-585. DOI: 10.1038/s44220-023-00101-4.Peer-Reviewed Original ResearchNeurobiological factorsPsychopathology symptomsFactor scoresCanonical brain networksThree-factor structureStructural equation modelingCritical developmental periodGray matter volumeCortical thicknessGreater genetic riskDisorder symptomatologyABCD studyEarly adolescenceDefault modeBrain networksAnxiety disordersGenetic riskIntervention effortsABCD cohortEquation modelingSubcortical gray matter volumesPsychopathology factorDevelopmental periodFear factorBrain structures21. Associations of Physical Frailty With Health Outcomes and Brain Structure in 483,033 Adults From the UK Biobank
Jiang R, Noble S, Sui J, Calhoun V, Scheinost D. 21. Associations of Physical Frailty With Health Outcomes and Brain Structure in 483,033 Adults From the UK Biobank. Biological Psychiatry 2023, 93: s77-s78. DOI: 10.1016/j.biopsych.2023.02.204.Peer-Reviewed Original ResearchAssociations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank
Jiang R, Noble S, Sui J, Yoo K, Rosenblatt M, Horien C, Qi S, Liang Q, Sun H, Calhoun V, Scheinost D. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank. The Lancet Digital Health 2023, 5: e350-e359. PMID: 37061351, PMCID: PMC10257912, DOI: 10.1016/s2589-7500(23)00043-2.Peer-Reviewed Original ResearchConceptsPopulation-based studyPhysical frailtyHealth-related outcomesBrain structuresMental healthHealth outcomesHealth measuresTotal white matter hyperintensitiesIndicators of frailtySeverity of frailtyLower gray matter volumePoor physical fitnessWhite matter hyperintensitiesGray matter volumeUK BiobankHealth-related measuresPoor mental healthMental health measuresDirection of associationMatter hyperintensitiesUnhealthy lifestyleEarly-life risksPsychiatric disordersNumerous confoundersPreventative strategies
2022
Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank
Jiang R, Westwater ML, Noble S, Rosenblatt M, Dai W, Qi S, Sui J, Calhoun VD, Scheinost D. Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank. BMC Medicine 2022, 20: 286. PMID: 36076200, PMCID: PMC9461129, DOI: 10.1186/s12916-022-02490-2.Peer-Reviewed Original ResearchConceptsGray matter volumeMental healthBrain structuresCognitive declineMatter volumeMental health outcomesHigher life satisfactionBetter mental healthBaseline grip strengthNeural correlatesCognitive functioningCognitive performanceBaseline neuroticismAnxiety symptomsBehavioral outcomesLife satisfactionMediation analysisNeuroimaging datasetsTemporal cortexOlder adultsLinear mixed effects modelsSubcortical regionsFinancial satisfactionLongitudinal dataGrip strength
2019
The Application of Connectome-Based Predictive Modeling to the Maternal Brain: Implications for Mother–Infant Bonding
Rutherford HJV, Potenza MN, Mayes LC, Scheinost D. The Application of Connectome-Based Predictive Modeling to the Maternal Brain: Implications for Mother–Infant Bonding. Cerebral Cortex 2019, 30: 1538-1547. PMID: 31690936, PMCID: PMC7132918, DOI: 10.1093/cercor/bhz185.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingAuditory networkMaternal anxietyMaternal bondingContext of anxietyMaternal Brain NetworkMother-infant bondBrain functional connectivityChild developmentMother-infant bondingBrain networksFunctional connectivityAnxietyBehavioral qualitiesBonding relationshipsBonding impairmentBrain structuresMaternal brainMother's mindGreater segregationNetwork connectivityMindGreater integrationConnectivityMonths postpartum