1995
In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.
Shulman R, Bloch G, Rothman D. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8535-8542. PMID: 7567971, PMCID: PMC41002, DOI: 10.1073/pnas.92.19.8535.Peer-Reviewed Original ResearchConceptsCovalent phosphorylationGlycogen synthesisGlycogen synthaseMuscle glycogen synthaseVivo NMR methodsPositive allosteric effectorMetabolic control theoryAllosteric effectorsVivo regulationGSaseVivo NMR experimentsNMR experimentsPhosphorylationSynthesis fluxProximal stepMuscle glycogen synthesisSynthaseVivo NMRRegulationNMR methodsMetabolite levelsHuman muscleRat muscleEffectorsEnzyme
1991
Correlation of lactate and pH in human skeletal muscle after exercise by 1H NMR
Pan J, Hamm J, Hetherington H, Rothman D, Shulman R. Correlation of lactate and pH in human skeletal muscle after exercise by 1H NMR. Magnetic Resonance In Medicine 1991, 20: 57-65. PMID: 1943662, DOI: 10.1002/mrm.1910200107.Peer-Reviewed Original Research13C-NMR measurements of muscle glycogen during low-intensity exercise
Price T, Rothman D, Avison M, Buonamico P, Shulman R. 13C-NMR measurements of muscle glycogen during low-intensity exercise. Journal Of Applied Physiology 1991, 70: 1836-1844. PMID: 2055862, DOI: 10.1152/jappl.1991.70.4.1836.Peer-Reviewed Original ResearchConceptsLow-intensity exerciseMuscle glycogenLight exerciseProtocol 1Blood velocityHours of exerciseMaximum voluntary contractionMin of onsetExercised legNonexercised legFemoral arteryVoluntary contractionGlycogen repletionHeavy exercisePlantar flexionGastrocnemius muscleFemale subjectsGlycogen levelsGlycogen metabolismFive minutesExerciseGlycogenSubjectsMagnetic resonance spectroscopyLeg
1989
Natural-abundance 13C NMR study of glycogen repletion in human liver and muscle.
Jue T, Rothman D, Tavitian B, Shulman R. Natural-abundance 13C NMR study of glycogen repletion in human liver and muscle. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 1439-1442. PMID: 2922392, PMCID: PMC286711, DOI: 10.1073/pnas.86.5.1439.Peer-Reviewed Original Research
1988
Intracellular pH in human skeletal muscle by 1H NMR.
Pan J, Hamm J, Rothman D, Shulman R. Intracellular pH in human skeletal muscle by 1H NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 7836-7839. PMID: 3186694, PMCID: PMC282291, DOI: 10.1073/pnas.85.21.7836.Peer-Reviewed Original ResearchDetection of human muscle glycogen by natural abundance 13C NMR.
Avison M, Rothman D, Nadel E, Shulman R. Detection of human muscle glycogen by natural abundance 13C NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 1634-1636. PMID: 3422752, PMCID: PMC279828, DOI: 10.1073/pnas.85.5.1634.Peer-Reviewed Original Research
1985
Application of multipulse NMR to observe 13C‐labeled metabolites in biological systems
Bendall M, Hollander J, Arias‐Mendoza F, Rothman D, Behar K, Shulman R. Application of multipulse NMR to observe 13C‐labeled metabolites in biological systems. Magnetic Resonance In Medicine 1985, 2: 56-64. PMID: 3831677, DOI: 10.1002/mrm.1910020107.Peer-Reviewed Original Research