2001
Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition
Patel A, Rothman D, Cline G, Behar K. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Research 2001, 919: 207-220. PMID: 11701133, DOI: 10.1016/s0006-8993(01)03015-3.Peer-Reviewed Original Research
1998
Measuring human brain GABA in vivo
Petroff O, Rothman D. Measuring human brain GABA in vivo. Molecular Neurobiology 1998, 16: 97-121. PMID: 9554704, DOI: 10.1007/bf02740605.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidGABA concentrationSeizure controlDaily doseRelease of GABACerebrospinal fluid GABA concentrationsGABA synthesisImproved seizure controlComplex partial seizuresPoor seizure controlTraditional antiepileptic drugsSingle oral doseEffects of vigabatrinElevated CSFImportant protective mechanismPartial seizuresOral doseSeizure disorderAntiepileptic drugsNonvesicular releaseSeizure activityGABA levelsTransporter reversalVigabatrin
1994
Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy
Mattson R, Petroff O, Rothman D, Behar K. Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy. Epilepsia 1994, 35: s29-s32. PMID: 8039467, DOI: 10.1111/j.1528-1157.1994.tb05963.x.Peer-Reviewed Original ResearchConceptsBrain GABA levelsGABA levelsHuman brain GABA levelsGeneralized tonic-clonic seizuresTonic-clonic seizuresGamma-aminobutyric acid transaminaseNew antiepileptic drugsElevated brain GABA levelsTimes control valuesLong-term trialsDaily dosageAntiepileptic drugsClinical effectsGABA elevationCerebrospinal fluidSide effectsMagnetic resonance spectroscopyControl valuesIrreversible substrateResonance spectroscopyFirst studyDosageConcentrations 2VigabatrinSeizures
1993
Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
Rothman D, Petroff O, Behar K, Mattson R. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 5662-5666. PMID: 8516315, PMCID: PMC46781, DOI: 10.1073/pnas.90.12.5662.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidGABA concentrationGABA-transaminase inhibitor vigabatrinBrain gamma-aminobutyric acidDose-dependent elevationSeizure suppressionOccipital lobeHigh doseNonepileptic subjectsHuman volunteersHuman cortexVigabatrinDrug vigabatrinBrainPatientsHuman brainVolunteersCortexDose