2009
Baseline brain energy supports the state of consciousness
Shulman RG, Hyder F, Rothman DL. Baseline brain energy supports the state of consciousness. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11096-11101. PMID: 19549837, PMCID: PMC2708743, DOI: 10.1073/pnas.0903941106.Peer-Reviewed Original ResearchConceptsLoss of consciousnessBrain energyConscious stateHigh-frequency neuronal activityCerebral energy consumptionBrain energy consumptionCerebral energyEnsembles of neuronsRat brainSomatosensory responsesNeuronal activityGamma-band rangeNeuronal propertiesFiring rateSensory stimulationNeuronal signalingPET measurementsAnesthesiaFMRI patternsFMRI activity patternsOxygen consumptionState of consciousnessStimulationBehavioral abilitiesMagnetic resonance spectroscopyHypoxic Injury during Neonatal Development in Murine Brain: Correlation between In Vivo DTI Findings and Behavioral Assessment
Chahboune H, Ment LR, Stewart WB, Rothman DL, Vaccarino FM, Hyder F, Schwartz ML. Hypoxic Injury during Neonatal Development in Murine Brain: Correlation between In Vivo DTI Findings and Behavioral Assessment. Cerebral Cortex 2009, 19: 2891-2901. PMID: 19380380, PMCID: PMC2774398, DOI: 10.1093/cercor/bhp068.Peer-Reviewed Original ResearchConceptsChronic sublethal hypoxiaLow birth weight preterm infantsBirth weight preterm infantsHypoxia-induced modificationNeonatal rodent modelPreterm birth resultsWeight preterm infantsSignificant neurodevelopmental disabilitiesOpen field taskGreater locomotor activityPreterm infantsPreterm birthNeurodevelopmental consequencesBirth resultsHypoxic injurySomatosensory cortexCaudate putamenCallosal connectivityCorpus callosumBehavioral deficitsNeurodevelopmental disabilitiesRodent modelsNeonatal developmentDTI findingsSublethal hypoxia
1999
Energy on demand.
Magistretti P, Pellerin L, Rothman D, Shulman R. Energy on demand. Science 1999, 283: 496-7. PMID: 9988650, DOI: 10.1126/science.283.5401.496.Peer-Reviewed Original Research