1998
Measuring human brain GABA in vivo
Petroff O, Rothman D. Measuring human brain GABA in vivo. Molecular Neurobiology 1998, 16: 97-121. PMID: 9554704, DOI: 10.1007/bf02740605.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidGABA concentrationSeizure controlDaily doseRelease of GABACerebrospinal fluid GABA concentrationsGABA synthesisImproved seizure controlComplex partial seizuresPoor seizure controlTraditional antiepileptic drugsSingle oral doseEffects of vigabatrinElevated CSFImportant protective mechanismPartial seizuresOral doseSeizure disorderAntiepileptic drugsNonvesicular releaseSeizure activityGABA levelsTransporter reversalVigabatrin
1996
Human brain GABA levels rise rapidly after initiation of vigabatrin therapy
Petroff O, Rothman D, Behar K, Collins T, Mattson R. Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology 1996, 47: 1567-1571.. PMID: 8960747, DOI: 10.1212/wnl.47.6.1567.Peer-Reviewed Original ResearchConceptsBrain GABA levelsBrain GABASingle oral doseOral doseGABA levelsSide effectsHuman brain GABA levelsEffective antiepileptic medicationsHours of administrationAntiepileptic medicationsVigabatrin therapyDay dosingIntractable epilepsySerial measurementsOccipital cortexVigabatrinDay 8Day 5GABAGABA transaminasePatientsDoseNext dayHuman brainMagnetic resonance spectroscopyHuman brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose
Petroff O, Rothman D, Behar K, Mattson R. Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose. Neurology 1996, 46: 1459-1463. PMID: 8628502, DOI: 10.1212/wnl.46.5.1459.Peer-Reviewed Original Research
1995
Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain
Petroff O, Rothman D, Behar K, Mattson R. Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain. Epilepsia 1995, 36: 457-464. PMID: 7614922, DOI: 10.1111/j.1528-1157.1995.tb00486.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidGABA levelsMumol/Antiepileptic drugsOccipital GABA levelsEffective antiepileptic drugEffects of vigabatrinStandard medicationStandard doseΓ-aminobutyric acidHealthy subjectsEpileptic patientsVigabatrinPatientsGABA transaminaseHuman cerebrumNoninvasive measurementHuman brainBrainGlutamateInitial observationsMedicationsCerebrumLevelsDoseVigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy
Mattson R, Petroff O, Rothman D, Behar K. Vigabatrin: effect on brain GABA levels measured by nuclear magnetic resonance spectroscopy. Acta Neurologica Scandinavica. Supplementum 1995, 92: 27-30. PMID: 7495186, DOI: 10.1111/j.1600-0404.1995.tb00496.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBrain GABA levelsGABA levelsBrain concentrationsNerve terminalsAdministration of vigabatrinClear dose-response relationshipLevels of GABAPartial epileptic seizuresAnti-epilepsy drugsPresynaptic nerve terminalsDose-response relationshipConcentration of GABASecondary generalizationClinical effectsClinical outcomesVigabatrin administrationClinical trialsPatient responseClinical studiesSynaptic transmissionBaseline valuesOptimal doseVigabatrin levelsVigabatrinEpileptic seizures
1994
Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy
Mattson R, Petroff O, Rothman D, Behar K. Vigabatrin: Effects on Human Brain GABA Levels by Nuclear Magnetic Resonance Spectroscopy. Epilepsia 1994, 35: s29-s32. PMID: 8039467, DOI: 10.1111/j.1528-1157.1994.tb05963.x.Peer-Reviewed Original ResearchConceptsBrain GABA levelsGABA levelsHuman brain GABA levelsGeneralized tonic-clonic seizuresTonic-clonic seizuresGamma-aminobutyric acid transaminaseNew antiepileptic drugsElevated brain GABA levelsTimes control valuesLong-term trialsDaily dosageAntiepileptic drugsClinical effectsGABA elevationCerebrospinal fluidSide effectsMagnetic resonance spectroscopyControl valuesIrreversible substrateResonance spectroscopyFirst studyDosageConcentrations 2VigabatrinSeizures
1993
Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
Rothman D, Petroff O, Behar K, Mattson R. Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 5662-5666. PMID: 8516315, PMCID: PMC46781, DOI: 10.1073/pnas.90.12.5662.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidGABA concentrationGABA-transaminase inhibitor vigabatrinBrain gamma-aminobutyric acidDose-dependent elevationSeizure suppressionOccipital lobeHigh doseNonepileptic subjectsHuman volunteersHuman cortexVigabatrinDrug vigabatrinBrainPatientsHuman brainVolunteersCortexDose