2004
Phosphorylation of Allosteric Enzymes Can Serve Homeostasis rather than Control Flux: The Example of Glycogen Synthase
Schafer J, Fell D, Rothman D, Shulman R. Phosphorylation of Allosteric Enzymes Can Serve Homeostasis rather than Control Flux: The Example of Glycogen Synthase. 2004, 59-71. DOI: 10.1002/0470011505.ch5.Peer-Reviewed Original Research
2001
Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy
Chase J, Rothman D, Shulman R. Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo13C/31P NMR spectroscopy. AJP Endocrinology And Metabolism 2001, 280: e598-e607. PMID: 11254467, DOI: 10.1152/ajpendo.2001.280.4.e598.Peer-Reviewed Original ResearchConceptsGlycogen synthesisGlycogen synthesis pathwayInsulin-stimulated muscle glycogen synthesisMetabolic control analysisMuscle glycogen synthesisGlycogen synthaseSynthesis pathwayGlycogen synthesis rateFlux controlGSaseHyperglycemic glucose concentrationsSynthesis rateControl coefficientsHexokinaseRat gastrocnemius muscleRelative contributionNMR spectroscopyGlycolysisSynthasePathway
1996
Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis.
Shulman R, Rothman D. Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7491-7495. PMID: 8755501, PMCID: PMC38772, DOI: 10.1073/pnas.93.15.7491.Peer-Reviewed Original ResearchConceptsCovalent phosphorylationGlycogen synthaseGlycogen synthesisGlucose transportMuscle glycogen synthaseAllosteric activationMetabolic control analysisMetabolic homeostasisPhosphorylationGlycogenic fluxEnzymatic phosphorylationHexokinase stepGSaseMuscle cellsHomeostasisFractional activityMuscle glycogen synthesisSynthaseConcentrations of G6PG6P concentrationActivityEnzymeMechanismRoleHexokinase
1995
In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.
Shulman R, Bloch G, Rothman D. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8535-8542. PMID: 7567971, PMCID: PMC41002, DOI: 10.1073/pnas.92.19.8535.Peer-Reviewed Original ResearchConceptsCovalent phosphorylationGlycogen synthesisGlycogen synthaseMuscle glycogen synthaseVivo NMR methodsPositive allosteric effectorMetabolic control theoryAllosteric effectorsVivo regulationGSaseVivo NMR experimentsNMR experimentsPhosphorylationSynthesis fluxProximal stepMuscle glycogen synthesisSynthaseVivo NMRRegulationNMR methodsMetabolite levelsHuman muscleRat muscleEffectorsEnzyme