2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
1996
Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain
Hwang J, Graham G, Behar K, Alger J, Prichard J, Rothman D. Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain. Magnetic Resonance In Medicine 1996, 35: 633-639. PMID: 8722812, DOI: 10.1002/mrm.1910350502.Peer-Reviewed Original ResearchConceptsSubacute stroke patientsProton magnetic resonance spectroscopicProton magnetic resonance spectroscopic imagingMagnetic resonance spectroscopic imagingStroke patientsHealthy subjectsMagnetic resonance spectroscopicMetabolite signal intensitiesBrain regionsPathological conditionsMacromolecule resonancesHuman brainBrainSignal intensitySubjectsRecovery timeSpectroscopic imagingPatients
1995
In Vivo Measurement of Phenylalanine in Human Brain by Proton Nuclear Magnetic Resonance Spectroscopy
Novotny E, Avison M, Herschkowitz N, Petroff O, Prichard J, Seashore M, Rothman D. In Vivo Measurement of Phenylalanine in Human Brain by Proton Nuclear Magnetic Resonance Spectroscopy. Pediatric Research 1995, 37: 244-249. PMID: 7731764, DOI: 10.1203/00006450-199502000-00020.Peer-Reviewed Original ResearchConceptsPhe concentrationsPlasma Phe concentrationsEfficacy of therapyCerebral concentrationsUntreated subjectsCerebral metabolitesNeurometabolic disorderControl studyPKU patientsPlasma PheMagnetic resonance spectroscopyMajor causePhenylketonuriaClinical magnetic resonance imaging systemNuclear magnetic resonance spectroscopyMagnetic resonance imaging systemHuman brainResonance imaging systemDisordersSubjectsImaging systemProton nuclear magnetic resonance spectroscopic studiesMagnetic resonance spectroscopic studiesResonance spectroscopyPHE signal
1994
NMR studies of human brain function
Shulman R, Rothman D, Blamire A. NMR studies of human brain function. Trends In Biochemical Sciences 1994, 19: 522-526. PMID: 7846759, DOI: 10.1016/0968-0004(94)90050-7.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPositron emission tomographyUnstimulated subjectsResonance imagingEmission tomographyBrain functionHuman brain functionSensory stimulationVisual stimulationBrain activityHuman brain activityHuman brainStimulationMetabolic rateSignificant improvementMagnetic resonance spectroscopySingle subjectSubjectsEstablished method
1993
Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans.
McCarthy G, Blamire A, Rothman D, Gruetter R, Shulman R. Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4952-4956. PMID: 8506340, PMCID: PMC46631, DOI: 10.1073/pnas.90.11.4952.Peer-Reviewed Original Research
1991
13C-NMR measurements of muscle glycogen during low-intensity exercise
Price T, Rothman D, Avison M, Buonamico P, Shulman R. 13C-NMR measurements of muscle glycogen during low-intensity exercise. Journal Of Applied Physiology 1991, 70: 1836-1844. PMID: 2055862, DOI: 10.1152/jappl.1991.70.4.1836.Peer-Reviewed Original ResearchConceptsLow-intensity exerciseMuscle glycogenLight exerciseProtocol 1Blood velocityHours of exerciseMaximum voluntary contractionMin of onsetExercised legNonexercised legFemoral arteryVoluntary contractionGlycogen repletionHeavy exercisePlantar flexionGastrocnemius muscleFemale subjectsGlycogen levelsGlycogen metabolismFive minutesExerciseGlycogenSubjectsMagnetic resonance spectroscopyLeg