2009
Baseline brain energy supports the state of consciousness
Shulman RG, Hyder F, Rothman DL. Baseline brain energy supports the state of consciousness. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11096-11101. PMID: 19549837, PMCID: PMC2708743, DOI: 10.1073/pnas.0903941106.Peer-Reviewed Original ResearchConceptsLoss of consciousnessBrain energyConscious stateHigh-frequency neuronal activityCerebral energy consumptionBrain energy consumptionCerebral energyEnsembles of neuronsRat brainSomatosensory responsesNeuronal activityGamma-band rangeNeuronal propertiesFiring rateSensory stimulationNeuronal signalingPET measurementsAnesthesiaFMRI patternsFMRI activity patternsOxygen consumptionState of consciousnessStimulationBehavioral abilitiesMagnetic resonance spectroscopy
2002
Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements
Hyder F, Kida I, Smith A, Blumenfeld H, Shulman R, Rothman D. Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements. International Congress Series 2002, 1235: 57-71. DOI: 10.1016/s0531-5131(02)00173-5.Peer-Reviewed Original ResearchMagnetic resonance imagingRat brainNeuronal activityFunctional MRIBOLD fMRI signalCerebral cortexNeuronal glucose oxidationRat cerebral cortexFunctional magnetic resonance imagingFMRI signalsBOLD functional MRIQuantitative magnetic resonance imagingBlood oxygenation levelBOLD fMRI studiesMulti-modal magnetic resonance imagingQuantitative functional MRIGlutamatergic neuronsOxygen deliveryPhysiologic basisResonance imagingPhysiologic componentsCMRO2BrainBlood circulationOxygenation level
2001
In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle flux
1992
NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain
Mason G, Rothman D, Behar K, Shulman R. NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 434-447. PMID: 1349022, DOI: 10.1038/jcbfm.1992.61.Peer-Reviewed Original Research
1987
Combined 1H and 31P NMR Studies of the Rat Brain in Vivo: Effects of Altered Intracellular pH on Metabolisma
BEHAR K, ROTHMAN D, FITZPATRICK S, HETHERINGTON H, SHULMAN R. Combined 1H and 31P NMR Studies of the Rat Brain in Vivo: Effects of Altered Intracellular pH on Metabolisma. Annals Of The New York Academy Of Sciences 1987, 508: 81-88. PMID: 3125776, DOI: 10.1111/j.1749-6632.1987.tb32896.x.Chapters
1984
Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo.
Rothman D, Behar K, Hetherington H, Shulman R. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6330-6334. PMID: 6149543, PMCID: PMC391917, DOI: 10.1073/pnas.81.20.6330.Peer-Reviewed Original Research