Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance Spectroscopy
Petroff O, Novotny E, Avison M, Rothman D, Alger J, Ogino T, Shulman G, Prichard J. Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 1022-1029. PMID: 1400641, DOI: 10.1038/jcbfm.1992.139.Peer-Reviewed Original ResearchConceptsBlood lactateLactate poolNuclear magnetic resonance spectroscopyMetabolic stateBrain lactateBlood gasesBlood glucoseElevated lactateMagnetic resonance spectroscopyProlonged elevationRabbit brainPerchloric acid extractsPathological conditionsBrain activationBrainResonance spectroscopyLactate turnoverHigh resolution 1H NMRIntracellular pHElectroshockLactateHuman brainVivo 1HSignificant changesAcid extractsSpectroscopic imaging of stroke in humans: histopathology correlates of spectral changes.
Petroff O, Graham G, Blamire A, Al-Rayess M, Rothman D, Fayad P, Brass L, Shulman R, Prichard J. Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes. Neurology 1992, 42: 1349-54. PMID: 1620345, DOI: 10.1212/wnl.42.7.1349.Peer-Reviewed Original ResearchConceptsCells/mm2Foamy macrophagesElevation of lactateGlial densityNeuropathologic examinationBrain macrophagesHuman strokeHistopathology correlateMacrophage densityInfarctsHigh lactateHistopathologic sectionsStrokeLactate concentrationMedial marginMacrophagesLactate signalMonthsLactate poolWeeksLactateCellular localizationMetabolic turnoverMagnetic resonanceMagnetic resonance spectroscopy