Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle model
Rothman D, Behar K, Dienel G. Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle model. Journal Of Neurochemistry 2022, 168: 555-591. PMID: 36089566, DOI: 10.1111/jnc.15619.Peer-Reviewed Original ResearchMitochondrial carriersSubcellular compartmentationCultured glutamatergic neuronsMechanistic basisMajor knowledge gapsMechanistic stoichiometryExtracellular GlnGlycolytic metabolismNeuronal compartmentsPre-synaptic structuresGlucose oxidationShuttle modelAlternative mechanismStoichiometric relationshipGlnDiseased brainNeuronal glucose metabolismMetabolismGluAminobutyric acidGlutamatergic neuronsKnowledge gapsCyclingMitochondriaCompartmentation