2024
Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides
Reshetnyak Y, Andreev O, Engelman D. Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides. Frontiers In Pharmacology 2024, 15: 1355893. PMID: 38545547, PMCID: PMC10965573, DOI: 10.3389/fphar.2024.1355893.Peer-Reviewed Original ResearchTumor microenvironmentTherapeutic agents to solid tumorsTargeted intracellular deliverySolid tumorsImmune cellsPHLIP technologyTargeted delivery of imagingPre-clinicalDelivery of imagingTherapeutic payloadsTumorTargeted deliveryIntracellular deliveryTumor imagingSimultaneous targetingClinical applicationTherapeutic deliveryCell typesSurface of cellsPHLIP peptidePHLIPDeliveryTarget biomarkersCellsMagic bullet
2006
ph‐Triggered Transport of Molecules into Cells by Transmembrane Helix Insertion
Engelman D, Andreev O, Reshetnyak Y. ph‐Triggered Transport of Molecules into Cells by Transmembrane Helix Insertion. The FASEB Journal 2006, 20: a457-a457. DOI: 10.1096/fasebj.20.4.a457-b.Peer-Reviewed Original ResearchC-terminusTransmembrane helix insertionActin cytoskeletonHelix insertionPlasma membraneTransbilayer helicesTarget cellsCell contractilityBiophysical measurementsCancer cellsDisulfide linksCytoplasmCellsWater-soluble peptidesDiseased tissuesPeptidesMembraneAcidic pHCytoskeletonFluorescent dyeHelixPhalloidinAcidic environmentMoleculesInjection of molecules